N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide | 1335010-50-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-2-(5,7-dimethyl-4,6-dioxo-4,5,6,7-tetrahydro[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide
• 英文别名: N-[4-[2,4-difluoro-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]-2-(5,7-dimethyl-4,6-dioxo-[1,2]oxazolo[3,4-d]pyrimidin-3-yl)acetamide
• CAS: 1335010-50-8
• 化学式: C₁₉H₁₂F₅N₅O₄S
• 分子量: 501.393
• InChiKey: NTFPIJYAGREYFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  137
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• TREATMENT OF RESPIRATORY DISORDERS USING TRPA1 ANTAGONISTS
  申请人：KHAIRATKAR-JOSHI Neelima

  公开号：US20120316136A1

  公开（公告）日：2012-12-13

  The present patent application relates to treatment of a respiratory disorder using TRPA1 antagonists. Particularly, the present patent application relates to treatment of a respiratory disorder using a TRPA1 antagonist, wherein the TRPA1 antagonist is administered by inhalation route to a subject in need thereof.
• PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND A STEROID
  申请人：Khairatakar-Joshi Neelima

  公开号：US20140148423A1

  公开（公告）日：2014-05-29

  The present patent application relates to a pharmaceutical composition comprising a transient receptor potential ankyrin-1 receptor (“TRPA1”) antagonist and a glucocorticoid.
• PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND AN ANTICHOLINERGIC AGENT
  申请人：GLENMARK PHARMACEUTICALS S.A.

  公开号：US20140364445A1

  公开（公告）日：2014-12-11

  The present invention relates to a pharmaceutical composition comprising a transient receptor potential ankyrin-1 receptor (“TRPA1”) antagonist and an anticholinergic agent. Particularly, the present invention provides a pharmaceutical composition comprising a TRPA1 antagonist having IC 50 for inhibiting human TRPA1 receptor activity of less than 1 micromolar and an anticholinergic agent; a process for preparing such composition; and its use in treating a respiratory disorder in a subject.
• US9186360B2
  申请人：——

  公开号：US9186360B2

  公开（公告）日：2015-11-17
• [EN] PHARMACEUTICAL COMPOSITION COMPRISING A TRPA1 ANTAGONIST AND A BETA-2 AGONIST<br/>[FR] COMPOSITION PHARMACEUTIQUE COMPRENANT UN ANTAGONISTE DE TRPA1 ET UN AGONISTE DE BÊTA-2
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2012176143A1

  公开（公告）日：2012-12-27

  The present patent application relates to a pharmaceutical composition comprising a transient receptor potential ankyrin-1 receptor ("TRPA1") antagonist and a beta-2 adrenergic receptor agonist ("beta-2 agonist").