Ethyl-pyridyl-(4)-ketimin | 16585-29-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Ethyl-pyridyl-(4)-ketimin
• 英文别名: 1-(Pyridin-4-yl)propan-1-imine；1-pyridin-4-ylpropan-1-imine
• CAS: 16585-29-8
• 化学式: C₈H₁₀N₂
• 分子量: 134.181
• InChiKey: RGKBTUZHZGFMRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.7
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] CHEMICAL ACTIVATORS OF NICOTINAMIDE MONONUCLEOTIDE ADENLYLY TRANSFERASE 2 (NMNAT2) AND USES THEREOF<br/>[FR] ACTIVATEURS CHIMIQUES DE MONONUCLÉOTIDE DE NICOTINAMIDE ADÉNYLYL TRANSFÉRASE 2 (NMNAT2) ET LEURS UTILISATIONS
  申请人：UNIV TSINGHUA

  公开号：WO2020107221A1

  公开（公告）日：2020-06-04

  The present application relates to novel semicarbazones and thiosemicarbazones, to processes for preparing them, to pharmaceutical preparations comprising them, to the use of the novel semicarbazones and thiosemicarbazones for treatment and/or prophylaxis of diseases and to the use thereof for production of a medicament for treatment and/or prophylaxis of diseases, especially of neurodegeneration and age-associated diseases or conditions associated with NAD loss. The present application also provides a method for high throughput screening of NMNAT2 activators.

  本申请涉及新型半胱氨酮和硫代半胱氨酮，以及制备它们的方法，包括含有它们的药物制剂，以及利用新型半胱氨酮和硫代半胱氨酮治疗和/或预防疾病的用途，以及用于生产治疗和/或预防疾病的药物的用途，特别是神经退行性疾病和与NAD损失相关的老年疾病或状况。本申请还提供了一种高通量筛选NMNAT2激活剂的方法。
• [EN] PROCESS FOR THE PREPARATION OF RIDINILAZOLE AND CRYSTALLINE FORMS THEREOF<br/>[FR] PROCÉDÉ DE PRÉPARATION DE RIDINILAZOLE ET DE FORMES CRISTALLINES DE CELUI-CI
  申请人：SUMMIT OXFORD LTD

  公开号：WO2021009514A1

  公开（公告）日：2021-01-21

  Described are processes for the preparation of 2,2'-di(pyridin-4-yl)-1H,1'H-5,5'- bibenzo[d]imidazole (which may also be known as 5,5'bis-[2-(4-pyridinyl)-1H- benzimidazole]), referenced herein by the INN name ridinilazole, and pharmaceutically acceptable derivatives, salts, hydrates, solvates, complexes, bioisosteres, metabolites or prodrugs thereof. The invention also relates to various compositions of purified ridinilazole, to various crystalline forms of ridinilazole, to processes for their preparation and to related pharmaceutical preparations and uses thereof (including their medical use and their use in the efficient large-scale synthesis of ridinilazole).

  介绍了制备2,2'-二(吡啶-4-基)-1H,1'H-5,5'-双苯并[d]咪唑(也可以被称为5,5'-双-[2-(4-吡啶基)-1H-苯并咪唑])的过程，该化合物在此处以国际非专利药品名称ridinilazole命名，以及其药学上可接受的衍生物、盐、水合物、溶剂化物、配合物、生物等效物、代谢物或前药。本发明还涉及纯化ridinilazole的各种组合物、ridinilazole的各种晶体形式、其制备过程以及相关的制药制剂和用途(包括其医学用途和在ridinilazole的高效大规模合成中的应用)。