Picolinic acid hydrate | 354527-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Picolinic acid hydrate
• 英文别名: pyridine-2-carboxylic acid;hydrate
• CAS: 354527-55-2
• 化学式: C6H7NO3
• 分子量: 141.12
• InChiKey: AGWSKXUJTPAZHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.04
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• 2-Aminoarylcarboxamides Useful as Cancer Chemotherapeutic Agents
  申请人：Brennan Catherine

  公开号：US20080293696A1

  公开（公告）日：2008-11-27

  A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents wherein the group R 4 represents halogen, CF 3 , or H, provided that the maximum number of CF 3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R 1 , R 2 and R 3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.

  化合物的化学式为(1)，其中含有E的环为苯环、吡啶环或嘧啶环。在公式(1)中，符号A代表，其中基团R4代表卤素、CF3或H，前提是任何A上CF3基团的最大数量为2，且与它们连接的碳原子形成6元环的A组的氢原子的最大数量为2，与它们连接的碳原子形成5元环的A组的氢原子的最大数量为1。当E形成苯环时，Z代表N或CH，当E形成吡啶环或嘧啶环时，Z代表CH。基团R1、R2和R3及下标a、b和d如所述和要求中定义。还披露和声明了含有化合物(1)的制药组合物和使用化合物(1)治疗癌症的方法。
• ISOTHIOUREA DERIVATIVES OR ISOUREA DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2415756A1

  公开（公告）日：2012-02-08

  The present invention provides, for example, a compound of the following formula (I): 1 wherein R1 is substituted amino and the like, R2 is halogen and the like, R3 is substituted or unsubstituted lower alkyl and the like, RA and RB are each independently hydrogen, substituted or unsubstituted lower alkyl and the like, RC and RD are each independently hydrogen, substituted or unsubstituted lower alkyl, or RC and RD together with the carbon atom to which they are attached may form a substituted or unsubstituted carbocycle, and ring A is a carbocycle or a heterocycle, its pharmaceutically acceptable salt, or a solvate thereof as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins.

  本发明提供了例如下式(I)的化合物：1 其中 R1 是取代的氨基等、 R2 是卤素等 R3 是取代或未取代的低级烷基等、 RA 和 RB 各自独立地为氢、取代或未取代的低级烷基等、 RC 和 RD 各自独立地为氢、取代或未取代的低级烷基，或 RC 和 RD 与它们所连接的碳原子一起可形成取代或未取代的碳环，以及 环 A 是碳环或杂环、 其药学上可接受的盐或其溶液作为治疗剂，用于治疗由淀粉样β蛋白的产生、分泌和/或沉积诱发的疾病。
• 2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS
  申请人：Bayer Pharmaceuticals Corporation

  公开号：EP1765811A2

  公开（公告）日：2007-03-28
• [EN] 2-AMINOARYLCARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS<br/>[FR] 2-AMINOARYLCARBOXAMIDES UTILES COMME AGENTS CHIMIOTHERAPEUTIQUES CONTRE LE CANCER
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2006002383A2

  公开（公告）日：2006-01-05

  A compound having the formula (1) in which the ring containing E is a phenyl, a pyridine, or a pyrimidine. In formula (1) the symbol A represents (see structures) wherein the group R4 represents halogen, CF3, or H, provided that the maximum number of CF3 groups on any A is 2, and the maximum number of hydrogens on A is 2 for the A groups which together with the carbon atoms to which they are attached form 6-membered rings, and the maximum number of hydrogens on A is 1 for the A group which together with the carbon atoms to which it is attached forms a 5-membered ring. Z represents N or CH when E forms a phenyl ring, and represents CH when E forms a pyridine or pyrimidine. The groups R1, R2 and R3 and the subscripts a, b, and d are as defined in the text and claims. Pharmaceutical compositions containing a compound of formula (1) and methods of treating cancer using compounds of formula (1) are also disclosed and claimed.
• [EN] 2-AMINOTHIOPHENECARBOXAMIDES USEFUL AS CANCER CHEMOTHERAPEUTIC AGENTS<br/>[FR] UTILISATION DE 2-AMINOTHIOPHENECARBOXAMIDES COMME AGENTS CHIMIOTHERAPEUTIQUES DANS LE TRAITEMENT DU CANCER
  申请人：BAYER PHARMACEUTICALS CORP

  公开号：WO2006023707A2

  公开（公告）日：2006-03-02

  This invention relates to novel 2-aminothiophenecarboxamide compounds, pharmaceutical compositions containing such compounds, and the use of those compounds or compositions as cancer chemotherapeutic agents.