(2E,4E)-(1S,3S,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-5-methylene-19-oxo-25-((triethylsilyl)oxy)-18,27,28,29-tetra-oxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl octa-2,4-dienoate | 1383605-10-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: (2E,4E)-(1S,3S,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-5-methylene-19-oxo-25-((triethylsilyl)oxy)-18,27,28,29-tetra-oxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl octa-2,4-dienoate
• CAS: 1383605-10-4
• 化学式: C₇₄H₁₀₆O₁₄Si₂
• 分子量: 1275.82
• InChiKey: QWFXYKPDKBPMRN-BQUFSFRHSA-N

反应信息

• 作为反应物：
  描述：

  (2E,4E)-(1S,3S,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-5-methylene-19-oxo-25-((triethylsilyl)oxy)-18,27,28,29-tetra-oxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl octa-2,4-dienoate 在 4-甲基苯磺酸吡啶 作用下， 以 甲醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

  摘要：

  The role of the C-8 gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.073
• 作为产物：
  描述：

  octadienoic anhydride 、 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以8.36 mg的产率得到(2E,4E)-(1S,3S,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-17-((R)-1-((benzyloxy)methoxy)ethyl)-21-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-((tert-butyldiphenylsilyl)oxy)-11-methoxy-13-(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-5-methylene-19-oxo-25-((triethylsilyl)oxy)-18,27,28,29-tetra-oxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl octa-2,4-dienoate
  参考文献：
  名称：

  Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity

  摘要：

  The role of the C-8 gem-dimethyl group in the A-ring of bryostatin 1 has been examined through chemical synthesis and biological evaluation of a new analogue. Assays for biological function using U937, K562, and MV4-11 cells as well as the profiles for downregulation of PKC isozymes revealed that the presence of this group is not a critical determinant for the unique pattern of biological activity of bryostatin. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.04.073