1-丁基-3-乙基硫脲 | 32900-06-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫脲类
• 中文名称: 1-丁基-3-乙基硫脲
• 英文名称: 1-Butyl-3-ethylthiourea
• CAS: 32900-06-4
• 化学式: C₇H₁₆N₂S
• mdl: MFCD04112849
• 分子量: 160.28
• InChiKey: HZSRFLLZMWDVEV-UHFFFAOYSA-N

物化性质

• 沸点：
  212.2±23.0 °C(Predicted)
• 密度：
  0.961±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  25.4
• 氢给体数：
  2
• 氢受体数：
  2

ADMET

毒理性

• 副作用

皮肤致敏剂 - 一种可以诱导皮肤产生过敏反应的制剂。

Skin Sensitizer - An agent that can induce an allergic reaction in the skin.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

在橡胶制造过程中，可能会因接触过程中使用的各种酸、碱、洗涤剂和溶剂而发生刺激性接触性皮炎。过敏性接触性皮炎也并不少见，几乎总是由有机加速剂或抗氧化剂引起。尽管潜在的致敏加速剂和抗氧化剂的清单非常庞大，但常见的过敏原包括......硫脲类。/硫脲类/

In the manufacture of rubber, irritant contact dermatitis may occur from a variety of acids, alkalies, detergents, and solvents used in the process. Allergic contact dermatitis occurs not infrequently and is almost always due to an organic accelerator or antioxidant. While the list of potential sensitizing accelerators and antioxidants is enormous, common allergens include ... thioureas. /Thioureas/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

在10名严重脚部皮炎患者中，发现他们对运动鞋内垫材料高度过敏。接触过敏测试显示对乙基丁基硫脲敏感。这种皮炎顽固不化，在许多案例中，即使停止穿着运动鞋后，病情仍会持续很长时间...

Ten patients with severe foot dermatitis were found to be highly allergic to innersole matl used in ... athletic shoes. Contact allergy testing showed sensitivity to ethylbutyl thiourea. The dermatitis was recalcitrant and in many cases persisted long after discontinuance of wearing /the athletic shoes/. ...

来源:Hazardous Substances Data Bank (HSDB)

文献信息

• NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Gopalan Balasubramanian

  公开号：US20090182143A1

  公开（公告）日：2009-07-16

  The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the Formula (1), their analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxide, pharmaceutically acceptable solvates and the pharmaceutical compositions containing them.

  本发明涉及新型杂环化合物、它们的类似物、互变异构体、位置异构体、立体异构体、对映异构体、顺反异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂和含有它们的制药组合物。本发明更特别地涉及式（1）的新型磷酸二酯酶4（PDE4）抑制剂、它们的类似物、互变异构体、对映异构体、顺反异构体、位置异构体、立体异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂和含有它们的制药组合物。
• 6-Epithioethyl-3-oxatricyclo (3.2.1.02.4) octane and process for preparation thereof
  申请人：NIPPON OIL CO. LTD.

  公开号：EP0452092A2

  公开（公告）日：1991-10-16

  6-Epithioethyl-3-oxatricyclo [3.2.1.02.4] octane, a novel compound, is prepared by reaction of the corresponding 6-epoxyethyl-3-oxatricyclo [3.2.1.02.4] octane with an ammonium or alkali or alkaline earth metal thiocyanate or a thiourea, and is useful as a monomer for preparation of, e.g., heat resistant plastics and plastics for optical use.

  6-环氧乙基-3-氧杂三环[3.2.1.02.4]辛烷是一种新型化合物，由相应的 6-环氧乙基-3-氧杂三环[3.2.1.02.4]辛烷与铵或碱或碱土金属硫氰酸盐或硫脲反应制备而成，可用作制备耐热塑料和光学塑料等的单体。
• LUBRICANT COMPOSITION
  申请人：Kamano Hideki

  公开号：US20130005624A1

  公开（公告）日：2013-01-03

  A lubricant oil composition which is excellent in deposition resistance, corrosion resistance and wear resistance, despite its low phosphorus content and low sulfuric acid ash content, is provided by using a succinimide compound in combination with at least one selected from specific sulfur-containing compounds, specific heterocyclic compounds and reaction products thereof.
• US3948904A
  申请人：——

  公开号：US3948904A

  公开（公告）日：1976-04-06
• US3994875A
  申请人：——

  公开号：US3994875A

  公开（公告）日：1976-11-30