N-cyclooctyl-3-formamido-2-hydroxybenzamide | 188756-52-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-cyclooctyl-3-formamido-2-hydroxybenzamide
• CAS: 188756-52-7
• 化学式: C₁₆H₂₂N₂O₃
• 分子量: 290.362
• InChiKey: SFEQPVHAZHBIHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES
  申请人：Stemergie Biotechnology SA

  公开号：EP2643300A1

  公开（公告）日：2013-10-02
• [EN] INHIBITORS OF THE ACTIVITY OF COMPLEX III OF THE MITOCHONDRIAL ELECTRON TRANSPORT CHAIN AND USE THEREOF FOR TREATING DISEASES<br/>[FR] INHIBITEURS DE L'ACTIVITÉ DU COMPLEXE III DE LA CHAÎNE MITOCHONDRIALE DE TRANSFERT DES ÉLECTRONS ET UTILISATION DE CEUX-CI POUR TRAITER DES MALADIES
  申请人：STEMERGIE BIOTECHNOLOGY SA

  公开号：WO2012070015A1

  公开（公告）日：2012-05-31

  The present invention relates to compounds which are inhibitors of the activity of Complex III of the mitochondrial electron transport chain and pharmaceutical compositions comprising said compounds alone or in combination with other active agents. The present invention further relates to use of the compounds of the invention as medicaments or as agrochemicals where their properties as inhibitors of the mitochondrial respiration is of benefit. More particularly the present invention relates to the use of the compounds of the invention in a method of treating and/or preventing cancers presenting tumor-initiating cells. (Formula I) (I)