tert-butyl(4-chlorobenzyl)carbamic chloride | 55246-37-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl(4-chlorobenzyl)carbamic chloride
• CAS: 55246-37-2
• 化学式: C₁₂H₁₅Cl₂NO
• 分子量: 260.163
• InChiKey: CTDZZSKMCHNBFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  tert-butyl(4-chlorobenzyl)carbamic chloride 、 potassium ethyl xanthogenate 以 乙腈 为溶剂， 反应 0.25h， 生成 O-ethyl [tert-butyl-[(4-chlorophenyl)methyl]carbamoyl]sulfanylmethanethioate
  参考文献：
  名称：

  Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones

  摘要：

  It has been found that carbamoylxanthates derived from secondary t-butyl amines are stable compounds which function as efiicient sources of carbamoyl radicals. The carbamoylxanthates derived from t-butylbenzylamines can be efficiently transformed into 2- t-butylisoindolin-1-ones via an oxidative radical cyclization process. The carbamoylxanthates derived from N-t-butylamino olefins underwent the expected cyclization/xanthate-transfer process to afford the corresponding pyrrolidones and piperidones under thermally induced DLP fragmentation conditions and in the presence of catalytic Et3B in air, at room temperature. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.09.142
• 作为产物：
  描述：

  三光气 、 N-(4-氯苄基)-2-甲基-2-丙胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 生成 tert-butyl(4-chlorobenzyl)carbamic chloride
  参考文献：
  名称：

  Carbamoyl radicals from carbamoylxanthates: a facile entry into isoindolin-1-ones

  摘要：

  It has been found that carbamoylxanthates derived from secondary t-butyl amines are stable compounds which function as efiicient sources of carbamoyl radicals. The carbamoylxanthates derived from t-butylbenzylamines can be efficiently transformed into 2- t-butylisoindolin-1-ones via an oxidative radical cyclization process. The carbamoylxanthates derived from N-t-butylamino olefins underwent the expected cyclization/xanthate-transfer process to afford the corresponding pyrrolidones and piperidones under thermally induced DLP fragmentation conditions and in the presence of catalytic Et3B in air, at room temperature. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.09.142

文献信息

• FR2234293
  申请人：——

  公开号：——

  公开（公告）日：——