(2S,3S)-N-(5-methyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octan-3-amine | 863879-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,3S)-N-(5-methyl-2-methoxyphenyl)methyl-2-diphenylmethyl-1-azabicyclo[2.2.2]-octan-3-amine
• 英文别名: (2S,3S)-N-(5-methyl-2-methoxyphenyl)methyl-2-diphenylmethyl-l-azabicyclo[2.2.2]octan-3-amine；2-benzhydryl-N-[(2-methoxy-5-methylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine
• CAS: 863879-43-0
• 化学式: C₂₉H₃₄N₂O
• 分子量: 426.602
• InChiKey: OMBTXOIQSSBSPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pharmaceutical kit for oxygen-sensitive drugs
  申请人：Pfizer Products Inc.

  公开号：EP1243524A2

  公开（公告）日：2002-09-25

  Pharmaceutical kits are provided that reduce or prevent oxidative degradation of oxygen-sensitive pharmaceutically active ingredients in solid unit dosage forms that are supplied in oxygen permeable containers. Stabilization of the active ingredient is accomplished by incorporating an oxygen absorber into a sealed oxygen permeable container.

  所提供的药剂包可以减少或防止在透氧容器中供应的固体单位剂型中对氧敏感的药物活性成分的氧化降解。活性成分的稳定是通过在密封的透氧容器中加入氧气吸收剂来实现的。
• PHARMACEUTICAL PACKAGE FOR SIMULTANEOUSLY MAINTAINING LOW MOISTURE AND LOW OXYGEN LEVELS
  申请人：Pfizer Products Incorporated

  公开号：EP1771357A1

  公开（公告）日：2007-04-11
• Package and device for simultaneously maintaining low moisture and low oxygen levels
  申请人：Friesen T. Dwayne

  公开号：US20070163917A1

  公开（公告）日：2007-07-19

  The present invention relates to a device for reducing the oxygen content of the air surrounding pharmaceutical dosage forms contained within an oxygen-permeable bottle, while also maintaining a relatively low moisture level in said air during the shelf-life of the product. Accordingly, a pharmaceutical package contains a dessicant in a first sub-container and a self-activated oxygen-absorber in a second sub-container.
• US6688468B2
  申请人：——

  公开号：US6688468B2

  公开（公告）日：2004-02-10
• [EN] PHARMACEUTICAL PACKAGE FOR SIMULTANEOUSLY MAINTAINING LOW MOISTURE AND LOW OXYGEN LEVELS<br/>[FR] EMBALLAGE PHARMACEUTIQUE PERMETTANT DE MAINTENIR SIMULTANEMENT UN FAIBLE TAUX D'HUMIDITE ET UN FAIBLE TAUX D'OXYGENE
  申请人：PFIZER PROD INC

  公开号：WO2006008651A1

  公开（公告）日：2006-01-26

  The present invention relates to a device for reducing the oxygen content of the air surrounding pharmaceutical dosage forms contained within an oxygen-permeable bottle, while also maintaining a relatively low moisture level in said air during the shelf-life of the product. Accordingly, a pharmaceutical package contains a dessicant in a first sub-container and a self-activated oxygen-absorber in a second sub-container.