N-(2-aminoethyl)-2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)acetamide | 1391194-44-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-aminoethyl)-2-(4-tert-butyl-3-hydroxy-2,6-dimethylphenyl)acetamide
• CAS: 1391194-44-7
• 化学式: C₁₆H₂₆N₂O₂
• 分子量: 278.39
• InChiKey: OXWQEZCQDVNSNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• GEL COMPOSITIONS OF OXYMETAZOLINE AND METHODS OF USE
  申请人：Shanler Stuart D.

  公开号：US20130079379A1

  公开（公告）日：2013-03-28

  Embodiments relating to gels comprising imidazoline alpha agonists, such as, without limitation, oxymetazoline or a pharmaceutically acceptable salt thereof, and methods for treating diseases, such as, without limitation, rosacea, including, for example, erythematotelangiectatic rosacea, papulopustular rosacea, phymatous rosacea, ocular rosacea or combinations thereof; and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema or redness associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith or combinations thereof using such gels are described herein.

  本文描述了涵盖咪唑啉α激动剂的凝胶实施例，例如，但不限于甲醛唑啉或其药学上可接受的盐，并且描述了用这样的凝胶治疗疾病的方法，例如，但不限于酒渣鼻，包括红斑毛细血管扩张型酒渣鼻、丘疹脓疱型酒渣鼻、皮肤增厚型酒渣鼻、眼部酒渣鼻或其组合；以及与酒渣鼻相关的症状，例如丘疹、脓疱、酒渣鼻（皮肤增厚）、毛细血管扩张或与酒渣鼻相关的红斑或红色症状，其他皮肤红斑、毛细血管扩张、紫斑或类似症状以及与之相关的其他表现或其组合。
• Compositions and methods for treating ocular disorders
  申请人：RVL Pharmaceuticals, Inc.

  公开号：US10799481B1

  公开（公告）日：2020-10-13

  The present disclosure is directed to compositions comprising oxymetazoline and methods of treating various eye disorders related to drooping eyelids, such as ptosis, in a subject comprising administering to the subject compositions comprising oxymetazoline.

  本公开涉及包含羟甲唑啉的组合物，以及治疗与眼睑下垂有关的各种眼部疾病（如上睑下垂）的方法，包括向受试者施用包含羟甲唑啉的组合物。
• Oxymetazoline compositions
  申请人：RVL Pharmaceuticals, Inc.

  公开号：US10814001B1

  公开（公告）日：2020-10-27

  The present disclosure is directed to compositions comprising oxymetazoline and methods of stabilizing oxymetazoline compositions for long term storage.

  本公开涉及包含羟甲唑啉的组合物和稳定羟甲唑啉组合物以便长期储存的方法。
• Aqueous pharmaceutical solution comprising oxymetazoline and/or xylometazoline
  申请人：Böhme Frank

  公开号：US20060222718A1

  公开（公告）日：2006-10-05

  The present invention relates to a stable aqueous solution comprising oxymetazoline and/or xylometazoline, a zinc salt and a buffer salt. The aqueous solution is particularly suitable for local administration into the nose for decongesting the mucous membrane.

  本发明涉及一种稳定的水溶液，它包含氧甲唑啉和/或甲氧甲唑啉、锌盐和缓冲盐。该水溶液特别适用于鼻腔局部用药，以缓解鼻黏膜充血。
• EP1194164A4
  申请人：——

  公开号：EP1194164A4

  公开（公告）日：2004-09-08