5-Methyl-2-phenyl-2,3-dihydrothiophene | 1092960-75-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Methyl-2-phenyl-2,3-dihydrothiophene
• CAS: 1092960-75-2
• 化学式: C₁₁H₁₂S
• 分子量: 176.282
• InChiKey: DXRSLXXEMPYZQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-Bromo-1-phenylpent-4-ene-1-thiol 在 copper(l) iodide 、 potassium phosphate monohydrate 、 aluminum oxide 、 三乙胺 作用下， 以 乙腈 、 正己烷 为溶剂， 反应 0.5h， 以54%的产率得到5-Methyl-2-phenyl-2,3-dihydrothiophene
  参考文献：
  名称：

  “Ligand-Free” CuI-Catalyzed Highly Efficient Intramolecular S-Vinylation of Thiols with Vinyl Chlorides and Bromides

  摘要：

  With CuI as the catalyst and K3PO4 center dot 3H(2)O as the base, highly efficient intramolecular S-vinylation of thiols with vinyl chlorides or bromides was successfully implemented without the help of an additional ligand. Moreover, the competition experiments revealed that the 4-exo cyclization is fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo) of cyclization.

  DOI：

  10.1021/jo802235e

文献信息

• FLUORENE DERIVATIVES AND ORGANIC ELECTRONIC DEVICE USING THE SAME
  申请人：Bae Jae-Soon

  公开号：US20100071769A1

  公开（公告）日：2010-03-25

  Disclosed is a novel fluorene derivative and an organic electronic device using the same. The organic electronic device has excellent efficiency, driving voltage, and a lifespan.

  揭示了一种新型的芴衍生物，以及使用该芴衍生物的有机电子器件。该有机电子器件具有出色的效率、驱动电压和寿命。
• Antibacterial agents
  申请人：The University of Washington

  公开号：EP2295402A2

  公开（公告）日：2011-03-16

  Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

  提供了式(I)的抗菌化合物：以及其立体异构体、药学上可接受的盐、酯和原药；包含此类化合物的药物组合物；通过服用此类化合物治疗细菌感染；以及制备这些化合物的工艺。
• ANTIBACTERIAL AGENTS
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP1618087B1

  公开（公告）日：2012-06-13
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3549944B1

  公开（公告）日：2021-12-29
• ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME, AND ELECTRONIC APPARATUS INCLUDING THE ORGANIC LIGHT-EMITTING DEVICE
  申请人：Samsung Electronics Co., Ltd.

  公开号：EP3715355B1

  公开（公告）日：2022-12-14