Acetic acid (3S,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-4,4,13,14-tetramethyl-11-oxo-2,3,4,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl ester | 51231-34-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Acetic acid (3S,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-4,4,13,14-tetramethyl-11-oxo-2,3,4,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl ester
• CAS: 51231-34-6
• 化学式: C₃₁H₄₆O₃
• 分子量: 466.704
• InChiKey: YDAFLRWZGBRJEO-BRXLKGGPSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (3S,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-4,4,13,14-tetramethyl-11-oxo-2,3,4,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-yl ester 在 palladium on activated charcoal 硫酸 、 氢气 、 硝酸 作用下， 以 甲苯 为溶剂， -15.0~-12.0 ℃ 、234.42 kPa 条件下， 反应 3.27h， 生成 3β-acetoxy-7-amino-19-norlanosta-5,7,9-trien-11-one
  参考文献：
  名称：

  Studies of B-ring aromatic tetracyclic Triterpenoid Derivatives

  摘要：

  By treatment of methyl 3beta-acetoxy-7beta-hydroxy-4, 4,14-trimethyl-1-oxo-5alpha-chol-8-en-24-oate 3 with p-toluenesulfonyl chloride in pyridine methyl 3beta-acetoxy-4,4,14-trimethyl-11-oxo19-norchola-5,7,9-trien-24-oate 1a was synthesized and its structure confirmed by spectral evidence. From 3beta-acetoxy-19-norlanosta-5,7,9-trien-11-one 1b the 7-amino derivative 1d, of which was prepared by nitration and selective catalytic hydrogenation (10% Pd/C) of the obtained 7-nitro compound 1c.

  DOI：

  10.1002/prac.19923340604