D-谷氨酸,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-羧基-1-羰基丙基)-4-(磺氨基)-L-苯基丙氨酰]-L-a-谷氨酰]-L-脯氨酰]-L-异白氨酰]-L-脯氨酰]-L-a-谷氨酰]-L-a-谷氨酰]-L-丙氨酰]-3-环己基-L-丙氨酰]- | 131831-88-4

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 中文名称: D-谷氨酸,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-羧基-1-羰基丙基)-4-(磺氨基)-L-苯基丙氨酰]-L-a-谷氨酰]-L-脯氨酰]-L-异白氨酰]-L-脯氨酰]-L-a-谷氨酰]-L-a-谷氨酰]-L-丙氨酰]-3-环己基-L-丙氨酰]-
• 英文名称: Suc-Phe(p-NHSO3H)-Glu-Pro-Ile-Pro-Glu-Glu-Ala-Cha-D-Glu-OH
• CAS: 131831-88-4
• 化学式: C₆₁H₈₇N₁₁O₂₄S
• 分子量: 1390.49
• InChiKey: XIRASVATJOLACM-MMVZGAKKSA-N

物化性质

• 密度：
  1.422±0.06 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  Suc-Phe(p-NH2)-Glu-Pro-Ile-Pro-Glu-Glu-Ala-Cha-D-Glu-OH 在 吡啶 、 pyridine-SO3 complex 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以52%的产率得到D-谷氨酸,N-[N-[N-[N-[N-[1-[N-[1-[N-[N-(3-羧基-1-羰基丙基)-4-(磺氨基)-L-苯基丙氨酰]-L-a-谷氨酰]-L-脯氨酰]-L-异白氨酰]-L-脯氨酰]-L-a-谷氨酰]-L-a-谷氨酰]-L-丙氨酰]-3-环己基-L-丙氨酰]-
  参考文献：
  名称：

  Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides

  摘要：

  C-Terminal fragment analogues of the leech protein hirudin or the related protein hirudin PA block thrombin's cleavage of fibrinogen. Three series of synthetic peptides were synthesized to study the effects of sulfation in hirudin-derived peptides. Potency of hirudin analogues increased with p-(amino)Phe63, p-(aminosulfonate)Phe63, and p-(sulfate)Tyr63 substitution in place of Tyr63. Sulfation of Tyr56, which in hirudin is normally Phe, resulted in a loss of 1 order of magnitude in potency. The sulfation of Tyr64 of the hirudin PA related analogue resulted in increased potency as for the hirudin analogue. However, in this series the p-(amino)Phe64 and p-(amino-sulfonate)Phe64 did not have increased potency. In addition to these positional effects, replacing all the Glu residues with (O-sulfato)Ser yielded an analogue with full antithrombin potency.

  DOI：

  10.1021/jm00107a043