| 955035-00-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 955035-00-4
• 化学式: C₁₃H₁₅ClN₂O₂
• 分子量: 266.727
• InChiKey: FXHDOTULFNMQEO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 sodium methansulfinate 以 N,N-二甲基甲酰胺 为溶剂， 生成 6,7-Dimethoxy-2-methylsulfonyl-3-propylquinoxaline
  参考文献：
  名称：

  Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

  摘要：

  Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor. (C) Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.086
• 作为产物：
  描述：

  6,7-dimethoxy-3-propylquinoxalin-2-ol 在 三氯氧磷 作用下， 生成
  参考文献：
  名称：

  Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

  摘要：

  Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor. (C) Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.06.086