Monopyridoxincitrat | 4589-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: Monopyridoxincitrat
• 英文别名: 5-hydroxy-3,4-bis(hydroxymethyl)-6-methylpyridinium dihydrogen citrate；4,5-Bis(hydroxymethyl)-2-methylpyridin-1-ium-3-ol;2-(carboxymethyl)-2,4-dihydroxy-4-oxobutanoate
• CAS: 4589-04-2
• 化学式: C₆H₈O₇*C₈H₁₁NO₃
• 分子量: 361.306
• InChiKey: DYAXNXLVEDEAER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.17
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  210
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Ion-pair delivery system for cosmetic and pharmaceutical compositions
  申请人：——

  公开号：US20040228884A1

  公开（公告）日：2004-11-18

  This invention relates to a novel ion-pair delivery system useful for cosmetic, pharmaceutical, and topical nutraceutical applications in which the functional performance and consumer aesthetics of an electron donor composition and an electron acceptor composition, or a proton donor composition and a proton acceptor composition, are synergistically enhanced when such compositions are combined in an ion-pair mode. During ion-pair bonding process, the electron donor composition or the proton acceptor composition become positively charged and the electron acceptor composition or proton donor composition become negatively charged and thus bind together in an ionic manner. Such ion-pair compositions release their electronically bound components in their original state when such compositions are absorbed into skin and reach physiological pH conditions.

  本发明涉及一种新型离子对传递系统，可用于化妆品、药品和局部营养品应用中，其中当电子给体组成物和电子受体组成物，或质子给体组成物和质子受体组成物以离子对模式结合时，其功能性能和消费者美学效果得到协同增强。在离子对键合过程中，电子给体组成物或质子受体组成物变为带正电荷，而电子受体组成物或质子给体组成物则变为带负电荷，从而以离子方式结合在一起。这样的离子对组成物在吸收到皮肤并达到生理pH条件时，释放其电子结合的成分。
• Hydroxy acids based delivery systems for skin resurfacing and anti-aging compositions
  申请人：——

  公开号：US20040092482A1

  公开（公告）日：2004-05-13

  This invention relates to in-situ preparation of the derivatives of various hydroxy acids (HA), such as &agr;-(Alpha) Hydroxy Acids (AHA), &bgr;-(Beta) Hydroxy Acids (BHA), and Poly-Hydroxy Acids (PHA) with certain skin beneficial organic hetero-atom bases and their application in skin resurfacing (exfoliation), and in the synergistic treatment and regulation of topical disorders of skin such as skin aging, wrinkles, acne, rosacea, age-spots, canker sores, striae distensae (stretch marks), pimples, skin redness, and dry skin conditions of cracking, flaking, and scaling. Most HA derivatives produced by the in-situ method do not cause skin irritation and skin redness effects that are commonly experienced with AHA and BHA, yet there is no loss of their skin beneficial effects. These compositions can be traditional water and oil emulsions, liposomes, suspensions, colloids, solutions, masks, muds, serums, sprays, gels, lotions, creams, cleansers, and anhydrous systems, thus offering a wide choice of formulations to meet their consumer appeal and acceptance requirements.

  本发明涉及原位制备各种羟基酸（HA）的衍生物，如&agr;-（α）羟基酸（AHA）、&bgr；-(β)羟基酸 (BHA)、聚羟基酸 (PHA) 与某些对皮肤有益的有机杂原子基团的衍生物，并将其应用于焕肤（去角质）、协同治疗和调节皮肤局部疾病，如皮肤老化、皱纹、痤疮、红斑痤疮、老年斑、口腔溃疡、妊娠纹、丘疹、皮肤发红以及干性皮肤皲裂、脱皮和脱屑等。通过原位法生产的大多数 HA 衍生物不会造成 AHA 和 BHA 常见的皮肤刺激和皮肤发红现象，同时也不会失去对皮肤有益的功效。这些组合物可以是传统的水和油乳剂、脂质体、悬浮液、胶体、溶液、面膜、泥浆、精华液、喷雾剂、凝胶、乳液、膏霜、清洁剂和无水体系，因此可提供多种配方选择，以满足消费者的吸引力和接受度要求。
• Concurrent Enhancement of Skin Penetration of Organic Base Active Agents and Organic Hydroxy Acid Active Agents as Their Ion-Pair Complexes
  申请人：Gupta K. Shyam

  公开号：US20060147508A1

  公开（公告）日：2006-07-06

  This invention relates to concurrent enhancement of skin penetration of certain organic nitrogen heterocyclic base active agents and certain organic acid active agents, especially organic hydroxy acids. This concurrent enhancement of skin penetration also provides enhanced bioavailability of both organic nitrogen heterocyclic base active agent and organic hydroxy acid active agent. The organic nitrogen heterocyclic base active agents and organic hydroxy acid active agents are first combined to form an ion-pair complex, which includes an in-situ mixing process, and said ion-pair complex is applied topically, whereupon said ion-pair complex undergoes enhanced skin penetration and upon reaching uppermost living part of skin and having reached therein the physiological pH of 7.4, said ion-pair complex dissociates to release its constituent organic nitrogen heterocyclic base active agent and said organic acid active agent in a bioavailable form.

  本发明涉及同时增强某些有机氮杂环基活性剂和某些有机酸活性剂，特别是有机羟基酸的皮肤渗透性。同时增强皮肤渗透力还能提高有机氮杂环基活性剂和有机羟基酸活性剂的生物利用度。首先将有机氮杂环基活性剂和有机羟基酸活性剂结合在一起，形成离子对复合物，其中包括一个原位混合过程，然后将所述离子对复合物局部涂抹，此时所述离子对复合物的皮肤渗透性增强，当到达皮肤的最上层生物部分并达到 7.4 的生理 pH 值时，所述离子对复合物解离，以生物可利用的形式释放出其成分有机氮杂环基活性剂和所述有机酸活性剂。
• Topically Bioavailable Acne and Rosacea Treatment Compositions
  申请人：——

  公开号：US20040156873A1

  公开（公告）日：2004-08-12

  The present invention relates to acne and rosacea compositions by a six-prong synergistic combination treatment strategy that includes (1) control of excess sebum production, (2) control of undesirable bacteria or mites, (3) control of inflammation, (4) enhanced desquamation of follicular infundibulum cells, (5) reduction of irritation from anti-acne or rosacea compositions themselves, and (6) enhancement of the topical bioavailability of anti-acne and rosacea compositions. This is achieved by a synergistic combination of commonly utilized topical anti-acne and rosacea ingredients with a topical bioavailability enhancement composition, which results in enhanced anti-acne and rosacea action from such ingredients. Moreover, additional inclusion of an anti-inflammatory composition, and also a vascular micro-circulation enhancement composition, further results in synergistic superior anti-acne and rosacea benefits from such compositions. The present invention discloses additional surprising synergistic combinations for the control of acne and rosacea that are suitable for a variety of delivery systems and packaging forms.
• Cosmetic Dermabrasion Treatment System
  申请人：Gupta K. Shyam

  公开号：US20050037038A1

  公开（公告）日：2005-02-17

  The present invention provides a complementary three-step dermabrasion system that provides treatment for skin conditions such as acne scars, wound scars, and other visually unappealing skin disfigurements, which constitutes the following, (1) Dermal Resurfacing with an adhesive composition, (2) Dermal Polishing with a polishing composition, and (3) Dermal Regeneration with a collagen-building and cell-proliferative composition.