N-[(Z)-methoxyiminomethyl]-2-methyl-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]benzamide | 928787-41-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(Z)-methoxyiminomethyl]-2-methyl-4-[5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]benzamide
• CAS: 928787-41-1
• 化学式: C₂₀H₁₅Cl₃F₃N₃O₃
• 分子量: 508.712
• InChiKey: GAVOHPYPZSGBCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS FOR FELINES
  申请人：Intervet International B.V.

  公开号：EP3473101A1

  公开（公告）日：2019-04-24

  This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced methods.

  本发明涉及控制动物及其环境中寄生虫侵扰的方法，更具体地说，涉及使用异噁唑类药物控制动物体内或动物身上或动物环境中的寄生虫以及治疗动物寄生虫病的方法。异噁唑啉类包括 4-(异噁唑啉基)-苯甲酰胺类（特别是取代的 4-(5-(卤甲基)-5-苯基-异噁唑啉-3-基)-苯甲酰胺类）和 4-(异噁唑啉基)-硫代苯甲酰胺类（特别是取代的 4-(5-(卤甲基)-5-苯基-异噁唑啉-3-基)-硫代苯甲酰胺类）。本发明还涉及用于此类方法的包含异噁唑啉类化合物的组合物，使用异噁唑啉类化合物制造用于此类方法的药物，以及用于实施此类方法的包含异噁唑啉类化合物的试剂盒。本发明还涉及异噁唑类化合物作为药物的用途，特别是可用于上述方法的药物。
• ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS
  申请人：Heckeroth Anja Regina

  公开号：US20110059988A1

  公开（公告）日：2011-03-10

  This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenylisoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.
• [EN] ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS<br/>[FR] COMPOSTIONS D'ISOXAZOLINE ET LEUR UTILISATION EN TANT QU'ANTIPARASITAIRES
  申请人：INTERVET INT BV

  公开号：WO2009024541A2

  公开（公告）日：2009-02-26

  This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl- isoxazo lin-3 -yl)-benzamides) and 4-(isoxazolinyl)- benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.