(3-Hydroxy-pyrrolidin-1-yl)-[2-(4-iodo-2-methyl-phenylamino)-5-nitro-phenyl]-methanone | 277315-06-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-Hydroxy-pyrrolidin-1-yl)-[2-(4-iodo-2-methyl-phenylamino)-5-nitro-phenyl]-methanone
• 英文别名: (3-Hydroxypyrrolidin-1-yl)-[2-(4-iodo-2-methylanilino)-5-nitrophenyl]methanone
• CAS: 277315-06-7
• 化学式: C₁₈H₁₈IN₃O₄
• 分子量: 467.263
• InChiKey: AOSFPUICWOTETL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  98.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Combination chemotherapy
  申请人：——

  公开号：US20040171632A1

  公开（公告）日：2004-09-02

  Mitotic inhibitors such as paclitaxel have improved antitumor activity when used in combination with a selective MEK inhibitor, especially a phenyl amine compound of Formula I and II: 1

  有丝分裂抑制剂如紫杉醇在与选择性MEK抑制剂结合使用时，特别是Formula I和II的苯胺化合物，已提高抗肿瘤活性。
• Treatment of asthma with MEK inhibitors
  申请人：——

  公开号：US20040141924A1

  公开（公告）日：2004-07-22

  This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of Formula I and II: 1

  本发明提供了一种通过向需要治疗的患者施用有效量的选择性MEK抑制剂，特别是公式I和II的苯胺，来预防或治疗哮喘的方法。
• Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
  申请人：——

  公开号：US20030055095A1

  公开（公告）日：2003-03-20

  The present invention provides a method of treating or preventing neutrophil chemotaxis. Specifically, the present invention provides a method of treating or preventing neutrophil migration by administering to a patient a MEK inhibitor.

  本发明提供了一种治疗或预防中性粒细胞趋化的方法。具体来说，本发明提供了一种通过向患者施用 MEK 抑制剂来治疗或预防中性粒细胞迁移的方法。
• 2-(4-BROMO OR 4-IODO PHENYLAMINO) BENZOIC ACID DERIVATIVES AND THEIR USE AS MEK INHIBITORS
  申请人：Warner-Lambert Company LLC

  公开号：EP0993437B1

  公开（公告）日：2006-11-08
• TREATMENT OF ARTHRITIS WITH MEK INHIBITORS
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1143957A3

  公开（公告）日：2002-02-27