N-{(1S,2R)-2[(2-fluoro-4'{2-[(methylsulfonyl)amino]ethyl}biphenyl-4-yl)oxy]cyclopentyl}propane-2-sulfonamide | 1258963-92-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{(1S,2R)-2[(2-fluoro-4'{2-[(methylsulfonyl)amino]ethyl}biphenyl-4-yl)oxy]cyclopentyl}propane-2-sulfonamide
• 英文别名: N-[(1S,2R)-2-[3-fluoro-4-[4-[2-(methanesulfonamido)ethyl]phenyl]phenoxy]cyclopentyl]propane-2-sulfonamide
• CAS: 1258963-92-6
• 化学式: C₂₃H₃₁FN₂O₅S₂
• 分子量: 498.64
• InChiKey: IWEQFPLUXSDOQL-XZOQPEGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof
  申请人：Fliri Anton F. J.

  公开号：US20110105533A1

  公开（公告）日：2011-05-05

  The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

  本发明涉及一类化合物，包括化合物的药用可接受盐，其结构如式I所定义。本发明还涉及含有式I化合物的组合物和其用途。
• HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
  申请人：Fliri Anton F. J.

  公开号：US20120322823A1

  公开（公告）日：2012-12-20

  The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also directed to compositions containing and uses of the compounds of formula I.

  本发明涉及一类化合物，包括化合物的药学上可接受的盐，其结构如公式I所定义。本发明还涉及含有公式I化合物的组合物和其用途。
• US8278457B2
  申请人：——

  公开号：US8278457B2

  公开（公告）日：2012-10-02