5-Iodo-1-isopropylpyrazole | 1345471-54-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 5-Iodo-1-isopropylpyrazole
• 英文别名: 5-iodo-1-propan-2-ylpyrazole
• CAS: 1345471-54-6
• 化学式: C₆H₉IN₂
• 分子量: 236.05
• InChiKey: ZIGKBLQYJMQQQE-UHFFFAOYSA-N

物化性质

• 沸点：
  240.3±13.0 °C(Predicted)
• 密度：
  1.79±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN
  申请人：GLOBAL BLOOD THERAPEUTICS, INC.

  公开号：US20160031865A1

  公开（公告）日：2016-02-04

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适用于血红蛋白调节剂的化合物和药物组合物，以及它们的制备方法和中间体，以及用于治疗由血红蛋白介导的疾病和需要组织和/或细胞氧合的疾病的方法。
• Compounds and uses thereof for the modulation of hemoglobin
  申请人：Global Blood Therapeutics, Inc.

  公开号：US10100040B2

  公开（公告）日：2018-10-16

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.

  本文提供了适合作为血红蛋白调节剂的化合物和药物组合物、制备它们的方法和中间体，以及将它们用于治疗由血红蛋白介导的疾病和可从组织和/或细胞氧合中获益的疾病的方法。
• [EN] KRAS G12C INHIBITOR AND APPLICATION THEREOF<br/>[FR] INHIBITEUR DE KRAS G12C ET APPLICATION ASSOCIÉE<br/>[ZH] KRAS G12C抑制剂及其应用
  申请人：SHANGHAI DE NOVO PHARMATECH CO LTD

  公开号：WO2021063346A1

  公开（公告）日：2021-04-08

  一种新型的KRAS G12C抑制剂，如式（I）所示化合物、其异构体或药学上可接受的盐具有如下结构。如式（I）所示化合物及其组合物可以有效治疗与KRAS G12C相关的疾病，例如：癌症。
• BENZIMIDAZOLONE AND BENZOTHIAZOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3288936B1

  公开（公告）日：2020-05-06
• [EN] COMPOUNDS AND USES THEREOF FOR THE MODULATION OF HEMOGLOBIN<br/>[FR] COMPOSÉS ET LEURS UTILISATIONS POUR LA MODULATION DE L'HÉMOGLOBINE
  申请人：GLOBAL BLOOD THERAPEUTICS INC

  公开号：WO2014150289A1

  公开（公告）日：2014-09-25

  Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.