3-{[(4-methylphenyl)acetyl]amino}-4-pyridinecarboxylic acid | 1461601-03-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-{[(4-methylphenyl)acetyl]amino}-4-pyridinecarboxylic acid
• 英文别名: 3-[[2-(4-Methylphenyl)acetyl]amino]pyridine-4-carboxylic acid
• CAS: 1461601-03-5
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: XTGPCAVDIHSMNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  79.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] DEMETHYLASE ENZYMES INHIBITORS<br/>[FR] INHIBITEURS D'ENZYMES DE DÉMÉTHYLASE
  申请人：GLAXO GROUP LTD

  公开号：WO2013143597A1

  公开（公告）日：2013-10-03

  A compound of formula (I) and its use as an inhibitor of one or more histone demethylase enzymes.

  一种具有化学式（I）的化合物及其作为一个或多个组蛋白去甲基化酶的抑制剂的用途。
• Methods for treating T-cell acute lymphoblastic leukemia
  申请人：New York University

  公开号：US10206930B2

  公开（公告）日：2019-02-19

  The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.

  本发明涉及治疗T-ALL的方法，该方法涉及给药Jumonji D3（JMJD3）去甲基化酶抑制剂。本发明的另一个实施方案涉及抑制T-ALL细胞增殖和/或存活的方法，该方法涉及对T-ALL细胞群施用朱梦吉D3（JMJD3）去甲基化酶抑制剂。
• METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES
  申请人：University of Houston System

  公开号：EP3962559A1

  公开（公告）日：2022-03-09
• METHODS FOR TREATING T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
  申请人：AIFANTIS Iannis

  公开号：US20170042904A1

  公开（公告）日：2017-02-16

  The present invention is directed to methods of treating T-ALL that involve administering an inhibitor of jumonji D3 (JMJD3) demethylase. Another embodiment of the invention relates to methods inhibiting T-ALL cell proliferation and/or survival that involves administering an inhibitor of jumonji D3 (JMJD3) demethylase to a population of T-ALL cells.
• [EN] METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES<br/>[FR] MÉTHODES ET COMPOSITIONS POUR TRAITER UNE LÉSION INFLAMMATOIRE CHRONIQUE, UNE MÉTAPLASIE, UNE DYSPLASIE ET DES CANCERS DES TISSUS ÉPITHÉLIAUX
  申请人：UNIV HOUSTON SYSTEM

  公开号：WO2020219963A1

  公开（公告）日：2020-10-29

  The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of an epithelial tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic epithelial stem cells (PESCs) relative to normal epithelial stem cells in the tissue in which the PESCs are found. Representative epithelial tissues include pulmonary, genitourinary, gastrointestinal/esophageal, pancreatic and hepatic tissues.