21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-, sodium salt (1:2) | 93891-87-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 21H-Biline-8,12-dipropanoic acid, 2,17-diethenyl-1,10,19,22,23,24-hexahydro-3,7,13,18-tetramethyl-1,19-dioxo-, sodium salt (1:2)
• CAS: 93891-87-3
• 化学式: C33H36N4NaO6
• 分子量: 607.7
• InChiKey: GSIVPDBVFJFAAY-IXWDEDMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.15
• 重原子数：
  44
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  164
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Hesperetin and trans-resveratrol compositions and methods thereof
  申请人：Thornalley Paul John

  公开号：US11135145B2

  公开（公告）日：2021-10-05

  The invention relates to a composition, in particular to an oral anti-ageing composition for treating hair ageing. This invention is based on the observation that the combination of hesperetin, a flavanone, derivable from a natural rutinoside hesperetin 7-rutinoside (also known as hesperidin) in citrus, e.g., in Citrus aurantium L, Citrus sinensis, Zanthozylum gilletti, leaves of Agathosma serratifolia, and trans-resveratrol synergistically up-regulates NQO-1 in a gene expression assay. The combination also induces Glo1, decreases MG and MG-protein glycation, decreases insulin resistance, decreases fasting plasma glucose, induces modest weight loss, improves renal function, decreases vascular inflammation marker slCAM-1, improves arterial dilatation and decreases the risk of cardiovascular disease. Thus is one aspect of the invention, a composition is provided, the composition comprising a combination of: (a) 30-10000, preferably 60-5000, most preferably 60-2500 mg in the form of an equivalent daily dose of flavanone of structure (I) wherein R is —H or —CH3, and mono-, di- and tri-acylated derivatives thereof; and (b) 20-1000, preferably 45-750, most preferably 45-500 mg in the form of an equivalent daily dose stilbenoid, wherein the composition comprises at least 0.5% w/w flavanone of structure I.

  本发明涉及一种组合物，特别是一种用于治疗头发老化的口服抗衰老组合物。本发明基于以下观察结果：在基因表达试验中，橙皮素（一种黄烷酮，可从柑橘中的天然芸香糖苷橙皮素 7-芸香糖苷（又称橙皮甙）衍生而来）与反式白藜芦醇的组合可协同上调 NQO-1。这种组合还能诱导 Glo1，减少 MG 和 MG 蛋白糖化，降低胰岛素抵抗，降低空腹血浆葡萄糖，诱导适度减肥，改善肾功能，减少血管炎症标志物 slCAM-1，改善动脉扩张，降低心血管疾病风险。因此，本发明的一个方面是提供一种组合物，该组合物包含以下物质的组合：(a) 30-10000，优选 60-5000，最优选 60-2500 毫克，以等效日剂量的结构(I)黄酮的形式，其中 R 为-H 或-CH3，以及其单、二和三酰化衍生物；以及 (b) 20-1000，优选 45-750，最优选 45-500 毫克，以等效日剂量的类芪类的形式，其中该组合物包含至少 0.5% w/w 结构 I 的黄酮。
• COMPOSITION FOR HAIR FOLLICLE GROWTH
  申请人：Unilever PLC

  公开号：EP3399959A1

  公开（公告）日：2018-11-14
• US5928645A
  申请人：——

  公开号：US5928645A

  公开（公告）日：1999-07-27
• [EN] COMPOSITION FOR HAIR FOLLICLE GROWTH<br/>[FR] COMPOSITION DESTINÉE À LA CROISSANCE DE FOLLICULE PILEUX
  申请人：UNILEVER PLC

  公开号：WO2017080958A1

  公开（公告）日：2017-05-18

  The invention relates to a composition, in particular to an oral anti-ageing composition for treating hair ageing. This invention is based on the observation that the combination of hesperetin, a flavanone, derivable from a natural rutinoside hesperetin 7-rutinoside (also known as hesperidin) in citrus, e.g., in Citrus aurantium L, Citrus sinensis, Zanthozylum gilletti, leaves of Agathosma serratifolia, and trans-resveratrol synergistically up-regulates NQO-1 in a gene expression assay. The combination also induces Glo1, decreases MG and MG-protein glycation, decreases insulin resistance, decreases fasting plasma glucose, induces modest weight loss, improves renal function, decreases vascular inflammation marker slCAM-1, improves arterial dilatation and decreases the risk of cardiovascular disease. Thus is one aspect of the invention, a composition is provided, the composition comprising a combination of: (a) 30-10000, preferably 60-5000, most preferably 60-2500 mg in the form of an equivalent daily dose of flavanone of structure (I) wherein R is -H or -CH3, and mono-, di- and tri-acylated derivatives thereof; and (b) 20-1000, preferably 45-750, most preferably 45-500 mg in the form of an equivalent daily dose stilbenoid, wherein the composition comprises at least 0.5 % w/w flavanone of structure I.