1-Ethyl-5-(2-(5-methanesulfonyl-pyridin-2-yl)5-trifluoromethyl-2H-pyrazol-3-yl]-2-methyl-1H-benzoimidazole | 343629-22-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-Ethyl-5-(2-(5-methanesulfonyl-pyridin-2-yl)5-trifluoromethyl-2H-pyrazol-3-yl]-2-methyl-1H-benzoimidazole
• 英文别名: 1-Ethyl-2-methyl-5-[2-(5-methylsulfonylpyridin-2-yl)-5-(trifluoromethyl)pyrazol-3-yl]benzimidazole
• CAS: 343629-22-1
• 化学式: C₂₀H₁₈F₃N₅O₂S
• 分子量: 449.456
• InChiKey: VJRDJLODCVUZKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  91
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS
  申请人：Pfizer Products Inc.

  公开号：EP1233959B1

  公开（公告）日：2005-03-16
• US6531492B1
  申请人：——

  公开号：US6531492B1

  公开（公告）日：2003-03-11
• [EN] HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS<br/>[FR] DERIVE HETEROCYCLO-ALKYLSULFONYLE PYRAZOLE EN TANT QU'AGENTS ANTI-INFLAMMATOIRES/ANALGESIQUES
  申请人：PFIZER PROD INC

  公开号：WO2001040216A1

  公开（公告）日：2001-06-07

  The present invention relates to compounds of formula (I) wherein R?2, R3, R6¿ and A are defined as in the specification, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the invention are useful in the treatment or alleviation of inflammation and other inflammation associated disorders, such as osteoarthritis, rheumatoid arthritis, colon cancer and Alzheimer's disease, in mammals (preferably humans, dogs, cats and livestock).