3-[1,2,2-Trimethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-5,6-dihydro-4H-[1,4]thiazine-2-carbonitrile | 154404-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 3-[1,2,2-Trimethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-5,6-dihydro-4H-[1,4]thiazine-2-carbonitrile
• CAS: 154404-74-7
• 化学式: C₁₆H₂₆N₂O₂S
• 分子量: 310.461
• InChiKey: YAZAQKPFPRDIQY-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  3-[1,2,2-Trimethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-5,6-dihydro-4H-[1,4]thiazine-2-carbonitrile 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 3-(1-Hydroxy-1,2,2-trimethyl-propyl)-5,6-dihydro-4H-[1,4]thiazine-2-carbonitrile
  参考文献：
  名称：

  2,3-Dihydro-4H-1,4-thiazines and 5,6-dihydro-3H-furo[3,4-b]-1,4-thiazines from 4-tetrahydropyranyloxyalk-2-ynenitriles.

  摘要：

  5-Cyano-6-(1-hydroxyalkyl)-4H-1,4-thiazines, derived from the corresponding 4-tetrahydropyranyloxyacetylenic nitriles, undergo base catalysed ring closure to give 3H-furo[3,4-b]-1,4-thiazines.

  DOI：

  10.1016/s0040-4039(00)73832-9
• 作为产物：
  描述：

  (Z)-3-(2-{2-[1-[1-Cyano-meth-(Z)-ylidene]-2,3,3-trimethyl-2-(tetrahydro-pyran-2-yloxy)-butylamino]-ethyldisulfanyl}-ethylamino)-4,5,5-trimethyl-4-(tetrahydro-pyran-2-yloxy)-hex-2-enenitrile 在 氧气 、 sodium ethanolate 作用下， 以 乙醇 为溶剂， 以62%的产率得到3-[1,2,2-Trimethyl-1-(tetrahydro-pyran-2-yloxy)-propyl]-5,6-dihydro-4H-[1,4]thiazine-2-carbonitrile
  参考文献：
  名称：

  2,3-Dihydro-4H-1,4-thiazines and 5,6-dihydro-3H-furo[3,4-b]-1,4-thiazines from 4-tetrahydropyranyloxyalk-2-ynenitriles.

  摘要：

  5-Cyano-6-(1-hydroxyalkyl)-4H-1,4-thiazines, derived from the corresponding 4-tetrahydropyranyloxyacetylenic nitriles, undergo base catalysed ring closure to give 3H-furo[3,4-b]-1,4-thiazines.

  DOI：

  10.1016/s0040-4039(00)73832-9