美托咪定杂质9 | 2250242-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 美托咪定杂质9
• 英文名称: N-Benzyl Medetomidine
• 英文别名: 1-benzyl-5-[1-(2,3-dimethylphenyl)ethyl]imidazole
• CAS: 2250242-52-3
• 化学式: C₂₀H₂₂N₂
• 分子量: 290.4
• InChiKey: SKGQKRSBNBDWDW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Detomidine Hydrochloride Crystallization Method
  申请人：Karjalainen Arto

  公开号：US20080287685A1

  公开（公告）日：2008-11-20

  A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with

  本发明提供了一种将地托咪定（I）盐酸盐分离为晶体盐的方法。该方法包括在含盐酸的水溶液中，在化合物公式（II）的催化剂存在下进行氢化反应，通过蒸馏浓缩溶液，可选地向浓缩溶液中添加盐酸，冷却浓缩溶液并回收结晶的地托咪定盐酸盐。该产品可以直接从水溶液中回收。
• READY-TO-USE DEXMEDETOMIDINE COMPOSITIONS
  申请人：SLAYBACK PHARMA LLC

  公开号：US20190262314A1

  公开（公告）日：2019-08-29

  The present invention provides stable, ready-to-use pharmaceutical compositions, comprising dexmedetomidine or a pharmaceutically acceptable salt thereof, one or more pharmaceutically acceptable excipients, and a pharmaceutically acceptable liquid vehicle, where the composition is provided in a sealed container that comprises a cyclic olefin polymer. The present invention also provides ready-to-use pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable liquid vehicle and an antioxidant and/or stabilizer, such as L-methionine. These solutions were found to be stable over the shelf life of the product. Other aspects of the invention relate to methods for making such compositions, as well as methods of using such compositions for perioperative care of a patient or for sedation.