N-(4-Bromo-2-methyl-6-nitrophenyl)butanamide | 765900-66-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-Bromo-2-methyl-6-nitrophenyl)butanamide
• CAS: 765900-66-1
• 化学式: C11H13BrN2O3
• 分子量: 301.14
• InChiKey: MISFQOYTYFBWAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel PPAR agonists, pharmaceutical compositions and uses thereof
  申请人：Pershadsingh A. Harrihar

  公开号：US20050020654A1

  公开（公告）日：2005-01-27

  The present invention provides novel compounds and pharmaceutical compositions thereof, which at least partially activate PPARγ and may further inhibit the activity of the AT1 receptor. The novel compounds include certain substituted benzimidazole compounds of Formulae I and II, infra. The invention also provides methods of treating inflammatory and metabolic disorders and methods for screening compounds for the capability to treat or prevent an inflammatory or metabolic disorder.

  本发明提供了新型化合物及其药物组合物，它们至少部分激活PPARγ，并可能进一步抑制AT1受体的活性。这些新型化合物包括下式I和II的某些取代苯并咪唑化合物。本发明还提供了治疗炎症和代谢性疾病的方法，以及筛选化合物以治疗或预防炎症或代谢性疾病的能力的方法。
• [EN] NOVEL PPAR AGONISTS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF<br/>[FR] NOUVEAUX AGONISTES PPAR, COMPOSITIONS PHARMACEUTIQUES ET LEURS UTILISATIONS
  申请人：BETHESDA PHARMACEUTICALS INC

  公开号：WO2004082621A2

  公开（公告）日：2004-09-30

  The present invention provides novel compounds and pharmaceutical compositions thereof, which at least partially activate PPARϜ and may further inhibit the activity of the AT1 receptor. The novel compounds include certain substituted benzimidazole compounds of Formulae I and II, infra. The invention also provides methods of treating inflammatory and metabolic disorders and methods for screening compounds for the capability to treat or prevent an inflammatory or metabolic disorder.