3-Chloro-2-(trifluoromethyl)thiophene | 143469-23-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 3-Chloro-2-(trifluoromethyl)thiophene
• CAS: 143469-23-2
• 化学式: C₅H₂ClF₃S
• 分子量: 186.58
• InChiKey: RKERFDGHTJHRNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] ORGANIC PHOTOELECTRIC CONVERSION DEVICES COMPRISING FLUORINATED DYE COMPOUNDS<br/>[FR] DISPOSITIFS DE CONVERSION PHOTOÉLECTRIQUE ORGANIQUE COMPRENANT DES COMPOSÉS DE COLORANTS FLUORÉS
  申请人：SOLVAY

  公开号：WO2015082222A1

  公开（公告）日：2015-06-11

  The present invention relates to organic photoelectric conversion devices comprising fluorinated dye compounds, in particular dye compounds based on fluoroalkyl-substituted thiophenes, method of making said dye compounds, and their use as dyes in organic photoelectric conversion devices.
• [EN] PYRIDIN-2-ONE COMPOUNDS USEFUL AS SMARCA2 ANTAGONISTS<br/>[FR] COMPOSÉS DE PYRIDIN-2-ONE UTILES EN TANT QU'ANTAGONISTES DE SMARCA2
  申请人：EPIZYME INC

  公开号：WO2020023657A1

  公开（公告）日：2020-01-30

  This disclosure generally relates to pyridine-2-one compounds of formula (I) and methods of using them in the treatment of a disorder, such as cancer or a SMARCA2-associated disorder, including as antagonists (e.g., inhibitors) of SMARCA2. The present disclosure provides treatment modalities, e.g., strategies, treatment methods, patient stratification methods, compounds, combinations, and compositions that are useful for the treatment of disorders, e.g., proliferative disorders, such as certain cancers. Some aspects of this disclosure provide treatment modalities, methods, strategies, compounds, compositions, combinations, and dosage forms for the treatment of cell proliferative disorders, e.g., cancers with decreased activity or function, or loss of function, of SMARCA4 with a SMARCA2 antagonist.