4-[ethyl(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile | 821777-63-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[ethyl(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
• CAS: 821777-63-3
• 化学式: C₁₂H₁₀F₆N₂
• 分子量: 296.215
• InChiKey: KZPQQMPMOYOBBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-(2,2,2-trifluoro-ethylamino)-2-trifluoromethyl-benzonitrile 、 碘乙烷 生成 4-[ethyl(2,2,2-trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile
  参考文献：
  名称：

  Chemical compounds

  摘要：

  本发明涉及非类固醇化合物，其是或被认为是雄激素、糖皮质激素、矿物质皮质激素和孕激素受体的调节剂，以及制备和使用此类化合物的方法。

  公开号：

  US20060148893A1

文献信息

• ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1654221A2

  公开（公告）日：2006-05-10
• PHARMACEUTICAL COMPOSITION FOR INHIBITING AMYLOID-BETA PROTEIN ACCUMULATION
  申请人：Motonaga Kozo

  公开号：US20100222434A1

  公开（公告）日：2010-09-02

  The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof; a method for inhibiting amyloid-β protein accumulation, comprising a step of administering an effective amount of the compound of the formula (I) or a pharmaceutically acceptable salt thereof to a mammal which may be diagnosed with an amyloid-β protein-related disease; and so on.
• [EN] ANILINE DERIVATIVED ANDROGEN-, GLUCOCORTICOID-, MINERALCORTICOID- AND PROGESTERONE- RECEPTOR MODULATORS<br/>[FR] COMPOSES CHIMIQUES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2005000795A2

  公开（公告）日：2005-01-06

  This invention relates to aniline derived non-steroidal compounds that are or are believed to be modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds.