1,2-bis-(tetradecyloxy)-3-dimethylamine propane | 175699-94-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-bis-(tetradecyloxy)-3-dimethylamine propane
• 英文别名: 1,2-Bis-(tetradecyloxy)-3-dimethylamino propane；N,N-dimethyl-2,3-di(tetradecoxy)propan-1-amine
• CAS: 175699-94-2
• 化学式: C₃₃H₆₉NO₂
• 分子量: 511.916
• InChiKey: ZVJAPVDDCYWINZ-UHFFFAOYSA-N

物化性质

• 沸点：
  565.1±35.0 °C(Predicted)
• 密度：
  0.862±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  13.4
• 重原子数：
  36
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2-bis-(tetradecyloxy)-3-dimethylamine propane 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 134.0h， 生成
  参考文献：
  名称：

  Synthesis of novel cationic cardiolipin analogues for the optimal delivery of therapeutic agents

  摘要：

  A novel approach was developed to synthesize cardiolipin analogues containing two quaternary ammonium groups With tetraalkyl chain retaining 'glycerol' moiety, the central core of the molecule. The analogues were synthesized with or without spacer and/or lipid chain length with saturation to tailor lipid-based formulations of therapeutic agents for optimal delivery to target sites. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.02.044
• 作为产物：
  描述：

  N-benzyl-N-methyl-2,3-di(tetradecoxy)propan-1-amine 在 palladium dihydroxide 氢气 作用下， 生成 1,2-bis-(tetradecyloxy)-3-dimethylamine propane
  参考文献：
  名称：

  Complex cationic lipids having quarternary nitrogens therein

  摘要：

  提供了具有衍生季铵头基的阳离子脂质体，其具有改进的细胞靶向能力和增强的转染效果，可用于向细胞中引入分子。

  公开号：

  US06670332B1

文献信息

• CORONAVIRUS VACCINE
  申请人：BioNTech RNA Pharmaceuticals GmbH

  公开号：EP3901261A1

  公开（公告）日：2021-10-27

  This disclosure relates to the field of RNA to prevent or treat coronavirus infection. In particular, the present disclosure relates to methods and agents for vaccination against coronavirus infection and inducing effective coronavirus antigen-specific immune responses such as antibody and/or T cell responses. Specifically, in one embodiment, the present disclosure relates to methods comprising administering to a subject RNA encoding a peptide or protein comprising an epitope of SARS-CoV-2 spike protein (S protein) for inducing an immune response against coronavirus S protein, in particular S protein of SARS-CoV-2, in the subject, i.e., vaccine RNA encoding vaccine antigen.

  该披露涉及RNA领域，用于预防或治疗冠状病毒感染。具体来说，本披露涉及用于预防冠状病毒感染和诱导有效的冠状病毒抗原特异性免疫应答（如抗体和/或T细胞应答）的方法和药剂。具体而言，在一种实施方式中，本披露涉及通过向受试者给予编码SARS-CoV-2尖刺蛋白（S蛋白）表位的肽或蛋白的RNA来诱导免疫应答，特别是在受试者中诱导对冠状病毒S蛋白的免疫应答，即编码疫苗抗原的疫苗RNA。
• Cytofectin dimers and methods of use thereof
  申请人：Vical Incorporated

  公开号：US06696424B1

  公开（公告）日：2004-02-24

  A composition is provided comprising a novel cationic lipid compound having hydrophobic tails and two quaternary ammonium headgroups bridged by a linker. The composition is useful as a cytofectin for facilitating delivery and transfection of biologically active agents, particularly anionic bioactive agents such as DNA, into cells. The composition is useful also as an adjuvant for enhancing the humoral immune response of a vertebrate to an immunogen, especially an immunogen encoded by a polynucleotide-based vaccine. In certain preferred embodiments, the cationic lipid compound is a dimer containing quaternary ammonium headgroups bridged by a linker having DNA and/or cell receptor binding affinity, such as a polypeptide or polyamine. Also disclosed is an immunogenic composition comprising an immunogen and the composition of the present invention.

  提供了一种组合物，其中包含一种新型阳离子脂质化合物，其具有疏水尾和两个季铵头基，由连接剂桥接。该组合物可用作细胞转染剂，以促进生物活性剂（特别是DNA等阴离子生物活性剂）的传递和转染到细胞中。该组合物还可用作佐剂，以增强脊椎动物对免疫原（特别是由多核苷酸疫苗编码的免疫原）的体液免疫反应。在某些优选实施例中，阳离子脂质化合物是一个二聚体，包含由DNA和/或细胞受体结合亲和力的季铵头基桥接的连接剂，例如多肽或多胺。本发明还公开了一种包含免疫原和本发明的组合物的免疫原组合物。
• Cationic cardiolipin analoges and its use thereof
  申请人：Ahmad U. Moghis

  公开号：US20050277611A1

  公开（公告）日：2005-12-15

  The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

  本发明提供了阳离子心磷脂化合物以及其合成和在脂质体制剂、基因转染等方面的使用方法。特别地，本发明提供了含阳离子心磷脂类似物的脂质体、含阳离子心磷脂类似物的药物组合物以及使用这些脂质体和组合物的方法，用于传递活性药物治疗人类和动物疾病和/或诊断测定。
• Novel lipids for transfection of nucleic acids
  申请人：Gebeyehu Gulilat

  公开号：US20050014962A1

  公开（公告）日：2005-01-20

  Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.

  本研究提供了阳离子脂质组合物，可用于将核酸等大分子有效地输送到各种真核细胞类型中。此外，还提供了使用这些组合物的方法。
• CATIONIC CARDIOLIPIN ANALOGS AND USE THEREOF
  申请人：Neopharm, Inc.

  公开号：EP1558562A1

  公开（公告）日：2005-08-03