1-Allyl-2,3-dihydro-1H-isoindole | 127797-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 1-Allyl-2,3-dihydro-1H-isoindole
• 英文别名: Allyl isoindoline；1-prop-2-enyl-2,3-dihydro-1H-isoindole
• CAS: 127797-14-2
• 化学式: C₁₁H₁₃N
• 分子量: 159.231
• InChiKey: KSXVMBMFVBPDSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-benzyloxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-decanoic acid methyl ester; compound with trifluoro-acetic acid 在 溶剂黄146 、 肼 作用下， 以 乙醇 、 水 为溶剂， 以72%的产率得到1-Allyl-2,3-dihydro-1H-isoindole
  参考文献：
  名称：

  Novel 1-substituted -2, 3-dihydro-1H-isoindoles: Synthesis via Meyers' methodology

  摘要：

  DOI：

  10.1016/s0040-4039(00)94570-2

文献信息

• PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS
  申请人：Chen Cheng

  公开号：US20130274463A1

  公开（公告）日：2013-10-17

  The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.

  本发明涉及大环内酰胺化合物，用于制备大环内酰胺的中间体，制备中间体的方法，以及制备和改性大环内酰胺的方法。本文描述的化合物和方法之一是用于生产能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。可以使用本文描述的程序合成HCV抑制化合物的例子是化合物A及其衍生物。
• COATING COMPOSITIONS, THEIR PREPARATION, AND COATED ARTICLES MADE THEREFROM
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP1706466A2

  公开（公告）日：2006-10-04
• US9120818B2
  申请人：——

  公开号：US9120818B2

  公开（公告）日：2015-09-01
• [EN] COATING COMPOSITIONS, THEIR PREPARATION, AND COATED ARTICLES MADE THEREFROM<br/>[FR] COMPOSITIONS DE REVETEMENT, PREPARATION DE CELLES-CI AINSI QU'ARTICLES REVETUS FABRIQUES A PARTIR DE CES COMPOSITIONS
  申请人：GEN ELECTRIC

  公开号：WO2005118731A2

  公开（公告）日：2005-12-15

  A coating composition comprising components A, B and optionally C, wherein component A comprises at least one hydroxy-terminated polyarylate. Component B is an organic species which can react with the hydroxy terminal groups of component A, and component C is a catalyst or mixture of catalysts. The hydroxy-terminated polyarylates are prepared by a solution polymerization method.
• [EN] PROCESS AND INTERMEDIATES FOR PREPARING MACROLACTAMS<br/>[FR] PROCÉDÉ ET INTERMÉDIAIRES POUR LA PRÉPARATION DE MACROLACTAMES
  申请人：MERCK SHARP & DOHME

  公开号：WO2012082672A2

  公开（公告）日：2012-06-21

  The present invention relates to macrolactam compounds, intermediates useful in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing and modifying macrolactams. One use of the compounds and methods described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. An example of an HCV inhibitory compound that can be synthesized using the procedures described herein is Compound A and derivative thereof.