guanosine epoxide | 60110-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: guanosine epoxide
• 英文别名: 9-(2,3-Anhydro-β-D-ribofuranosyl)guanin；2',3'-anhydro-guanosine；2-amino-9-[(1R,2R,4R,5R)-4-(hydroxymethyl)-3,6-dioxabicyclo[3.1.0]hexan-2-yl]-1H-purin-6-one
• CAS: 60110-87-4
• 化学式: C₁₀H₁₁N₅O₄
• 分子量: 265.228
• InChiKey: BARIOYCTUQXULP-UUOKFMHZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  guanosine epoxide 、 bis[(pivaloyloxy)methyl] chlorophosphate 在 N-甲基咪唑 、 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  [EN] SMALL MOLECULE FOR TREATMENT OF CANCER OF THE APPENDIX
  [FR] PETITE MOLÉCULE POUR LE TRAITEMENT DU CANCER DE L'APPENDICE

  摘要：

  This disclosure provides compounds, compositions and methods for one or more of: inhibiting the growth of a diseased cell mediated by GNAS activity; inhibiting the growth of a cancer cell, inhibiting the growth of a cancer cell mediated by GNAS activity, or assaying for inhibitory activity of a compound or pharmaceutical activity of a diseased cell in a subject in need thereof by administering to the subject an effective amount of a compound or composition of this disclosure. Also provided are compounds, compositions and methods for treating cancer in a patient in need thereof, by administering to the subject an effective amount of a compound or composition as disclosed herein.

  公开号：

  WO2024015641A1
• 作为产物：
  描述：

  鸟苷 在 氨 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 guanosine epoxide
  参考文献：
  名称：

  [EN] SMALL MOLECULE FOR TREATMENT OF CANCER OF THE APPENDIX
  [FR] PETITE MOLÉCULE POUR LE TRAITEMENT DU CANCER DE L'APPENDICE

  摘要：

  This disclosure provides compounds, compositions and methods for one or more of: inhibiting the growth of a diseased cell mediated by GNAS activity; inhibiting the growth of a cancer cell, inhibiting the growth of a cancer cell mediated by GNAS activity, or assaying for inhibitory activity of a compound or pharmaceutical activity of a diseased cell in a subject in need thereof by administering to the subject an effective amount of a compound or composition of this disclosure. Also provided are compounds, compositions and methods for treating cancer in a patient in need thereof, by administering to the subject an effective amount of a compound or composition as disclosed herein.

  公开号：

  WO2024015641A1