Acetic acid (4Z,6E)-18-methyl-2-oxo-azacyclooctadeca-4,6-dien-7-yl ester | 141920-65-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: Acetic acid (4Z,6E)-18-methyl-2-oxo-azacyclooctadeca-4,6-dien-7-yl ester
• CAS: 141920-65-2
• 化学式: C₂₀H₃₃NO₃
• 分子量: 335.487
• InChiKey: NCNFRVKJBFSXQL-BDXFUOSDSA-N

反应信息

• 作为产物：
  描述：

  Acetic acid 1-(11-tert-butoxycarbonylamino-dodecyl)-6-oxo-cyclohexa-2,4-dienyl ester 在 N-甲基咪唑 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 Acetic acid (4Z,6E)-18-methyl-2-oxo-azacyclooctadeca-4,6-dien-7-yl ester
  参考文献：
  名称：

  Photolactamization: A Novel Synthetic Entry into Large Ring-Sized Lactams

  摘要：

  Diene ketenes smoothly accessible by photochemical ring cleavage of omicron-quinol acetates, in the presence of primary or secondary amines afford the corresponding amides. In an intramolecular version of this reaction macrocyclic lactams of type A are produced, if aminoalkylated omicron-quinol acetates of type C are used as photo reactants. These photo reactants are available on acid mediated removal of the Boc-protecting group from Wessely acetoxylation products of type D, easily formed via compounds of type E from aminoalkylated phenols of type F.

  DOI：

  10.1016/0040-4039(92)88118-o