4,5,6-三硝基苯-1,2,3-三胺 | 67539-61-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4,5,6-三硝基苯-1,2,3-三胺
• 英文名称: ar,ar,ar-Trinitrobenzenetriamine
• 英文别名: 4,5,6-trinitrobenzene-1,2,3-triamine
• CAS: 67539-61-1
• 化学式: C6H6N6O6
• 分子量: 258.15
• InChiKey: MKWKGRNINWTHMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  216
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• IONIC LIQUID, A METHOD OF SYNTHESIZING AN IONIC LIQUID, A PRECURSOR OF AN EXPLOSIVE COMPOSITION INCLUDING AT LEAST ONE IONIC LIQUID, AND A METHOD OF DESENSITIZING AN EXPLOSIVE COMPOSITION
  申请人：Nicolich Steven M.

  公开号：US20080251169A1

  公开（公告）日：2008-10-16

  An ionic liquid is disclosed A precursor composition that comprises at least one ionic liquid and at least one energetic material is also disclosed, as is a method of synthesizing an ionic liquid and a method of desensitizing an explosive composition.

  本文披露了一种离子液体。还披露了一种包括至少一种离子液体和至少一种活性材料的前体组合物，以及一种合成离子液体的方法和一种降低爆炸组合物敏感性的方法。
• Synthesis and purification of 1,3,5-triamino-2,4,6-trinitrobenzene (TATB)
  申请人：Mitchell R. Alexander

  公开号：US20050038297A1

  公开（公告）日：2005-02-17

  A method to convert surplus nitroarene explosives (picric acid, ammonium picrate,) into TATB is described. The process comprises three major steps: conversion of picric acid/ammonium picrate into picramide; conversion of picramide to TATB through vicarious nucleophilic substitution (VNS) of hydrogen chemistry; and purification of TATB.

  描述了一种将过剩的硝基芳烃炸药（苦味酸、苦味酸铵）转化为TATB的方法。该过程包括三个主要步骤：将苦味酸/苦味酸铵转化为苦味酰胺；通过偏位亲核取代（VNS）氢化学将苦味酰胺转化为TATB；以及TATB的纯化。
• IBUPROFEN ESTER PRODRUG, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD AND USE
  申请人：Nanjing Heron Pharmaceutical Science and Technology Co., Ltd.

  公开号：EP3984989A1

  公开（公告）日：2022-04-20

  Provided is an ibuprofen ester prodrug represented by Structural Formula (1), a racemate, stereoisomer or pharmaceutically acceptable salt or solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof. Further provided are a method for preparing the compound, a pharmaceutical composition containing the compound, and an application of the compound in preparation of nonsteroidal anti-inflammatory drugs. The pharmaceutical composition containing the ibuprofen ester prodrug may be prepared into fat emulsion injection preparations. The ibuprofen ester prodrug has good stability and good pharmacokinetic properties and overcomes the problems of ibuprofen such as a short half-life, poor stability, irritation, and incompatibility.

  提供的是一种伊布普洛芬酯前药，其结构式表示为（1），可以是混合物、立体异构体或药学上可接受的盐或溶剂化物，或其药学上可接受的盐的溶剂化物。还提供了一种制备该化合物的方法，包含该化合物的制药组合物，以及该化合物在制备非甾体抗炎药方面的应用。含有伊布普洛芬酯前药的制药组合物可以制备成脂肪乳注射制剂。伊布普洛芬酯前药具有良好的稳定性和良好的药代动力学特性，克服了伊布普洛芬的问题，例如短半衰期、稳定性差、刺激性和不相容性。
• Synthesis of trinitrophloroglucinol and triaminotrinitrobenzene (TATB)
  申请人：Mitchell R. Alexander

  公开号：US20050070743A1

  公开（公告）日：2005-03-31

  A method to convert surplus nitroarene explosives into trinitrophloroglucinol and triaminotrinitrobenzene (TATB) is described. Picric acid is directly aminated to diaminopicric acid, which is converted to trinitrophloroglucinol and triaminotrinitrobenzene.

  一种将过剩的硝基芳烃炸药转化为三硝基邻苯三酚和三氨基三硝基苯（TATB）的方法被描述。苦味酸被直接氨化成二氨基苦味酸，然后转化成三硝基邻苯三酚和三氨基三硝基苯。
• SYSTEMS AND METHODS FOR CHEMICAL AND/OR MECHANICAL REMEDIATION OF NITRO COMPOUNDS AND NITRATE ESTERS
  申请人：Lubbe Carl Hermanus

  公开号：US20110041718A1

  公开（公告）日：2011-02-24

  Systems and methods for chemoremediation or mechanical destruction of undetonated explosive materials. An explosive apparatus contains an explosive material in close proximity to a chemical reagent selected for its chemoremediative properties. A barrier is interposed between the explosive material and the chemical reagent to delay the chemoremediation of the explosive material. Alternatively a water expandable material may be incorporated into the explosive material, whereby upon exposure to moisture the water absorbing material will expand sufficiently to fragment the explosive material into initiation insensitive particles. Initiation insensitivity is achieved by incorporation of water, which acts as a desensitizing agent as well as fragmenting the explosive material into particles sufficiently small that they are below the critical diameter for explosive initiation. The present invention also relates to self-degradable, shaped explosive formulations, comprising an explosive material and a water expandable material.

  化学修复或机械破坏未爆炸物质的系统和方法。爆炸装置包含一种爆炸物质，与一种选择其化学修复性能的化学试剂密切接触。在爆炸物质和化学试剂之间插入一道障碍物，以延迟爆炸物质的化学修复。或者，可将一种可膨胀的吸水材料并入爆炸物质中，当暴露于水分时，吸水材料将膨胀足够大，将爆炸物质分解成启动不敏感的颗粒。通过加入水来实现启动不敏感性，水既起到减敏剂的作用，又将爆炸物质分解成足够小的颗粒，使它们小于爆炸启动的临界直径。本发明还涉及自降解的成形爆炸配方，包括一种爆炸物质和一种可膨胀的吸水材料。