2-benzofuran-4-yl-N-[1-(3-phenylpropyl)piperidin-3-yl]acetamide | 401613-17-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzofuran-4-yl-N-[1-(3-phenylpropyl)piperidin-3-yl]acetamide
• 英文别名: 2-(1-benzofuran-4-yl)-N-[1-(3-phenylpropyl)piperidin-3-yl]acetamide
• CAS: 401613-17-0
• 化学式: C₂₄H₂₈N₂O₂
• 分子量: 376.499
• InChiKey: PYTAPFJPRDTCLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Bicyclic heteroaromatic derivatives for the treatment of immune and inflammatory disorders
  申请人：——

  公开号：US20030171413A1

  公开（公告）日：2003-09-11

  Compounds of formula (1) are described, wherein q is zero or the integer 1, 2 or 3; R which when present may be attached to any available carbon or nitrogen atom of the bicyclic heteroaromatic ring of formula (1) is an atom or group -L 3 (Alk 3 ) w L 4 (R 8 ) u ; X is an O atom or a S(O) m atom or group in which m is zero or the integer 1 or 2 or an NR group; Y is a N atom or a CR 1a group in which R 1a is a group R or a group R 1 ; R 1 which may he on any available carbon atom of the bicyclic heteroaromatic ring of formula (1) is a hydrogen atom or a group -Alk 1 L 1 CyAlk 2 L 2 D; provided that at least one but not both of R 1 and R 1a is the group -Alk 1 L 1 CyAlk 2 L 2 D. The compounds are potent inhibitors of the interaction between CCR-3 and it chemokine ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders in which inhibition of this interaction can have a beneficial effect.

  描述了式（1）的化合物，其中q为零或整数1、2或3；R，当存在时，可以连接到式（1）的双环杂芳环的任何可用碳或氮原子上，是一个原子或基团-L3(Alk3)wL4(R8)u；X为一个O原子或S(O)matom或基团，在其中m为零或整数1或2或一个NR基团；Y为一个N原子或CR1agroup，在其中R1a是一个基团R或一个基团R1；R1，可以位于式（1）的双环杂芳环的任何可用碳原子上，是一个氢原子或一个基团-Alk1L1CyAlk2L2D；但要求R1和R1a中至少一个而不是两者都是基团-Alk1L1CyAlk2L2D。这些化合物是CCR-3与其趋化因子配体之间相互作用的有效抑制剂，可用于预防和治疗通过抑制该相互作用可能产生有益效果的免疫或炎症性疾病。
• BICYCLIC HETEROAROMATIC DERIVATIVES FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS
  申请人：Celltech R&D Limited

  公开号：EP1311502A1

  公开（公告）日：2003-05-21
• [EN] BICYCLIC HETEROAROMATIC DERIVATIVES FOR THE TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS<br/>[FR] DERIVES HETEROAROMATIQUES BICYCLIQUES POUR LE TRAITEMENT DE TROUBLES IMMUNITAIRES ET DE TROUBLES INFLAMMATOIRES
  申请人：CELLTECH R&D LTD

  公开号：WO2002016353A1

  公开（公告）日：2002-02-28

  Compounds of formula (1) are described, wherein q is zero or the integer 1, 2 or 3; R which when present may be attached to any available carbon or nitrogen atom of the bicyclic heteroaromatic ring of formula (1) is an atom or group -L3(Alk3)wL4(R8)u;X is an O atom or a S(O)m atom or group in which m is zero or the integer 1 or 2 or an NR group; Y is a N atom or a CR1a group in which R1a is a group R or a group R1; R1 which may be on any available carbon atom of the bicyclic heteroaromatic ring of formula (1) is a hydrogen atom or a group -Alk?1L1CyAlk2L2¿D; provided that at least one but not both of R?1 and R1a¿ is the group -Alk?1L1CyAlk2L2¿D. The compounds are potent inhibitors of the interaction between CCR-3 and it chemokine ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders in which inhibition of this interaction can have a beneficial effect.