2',3'-dideoxy-E-5-styryluridine 5'-monophosphate | 158358-52-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 2',3'-dideoxy-E-5-styryluridine 5'-monophosphate
• CAS: 158358-52-2
• 化学式: C₁₇H₁₉N₂O₇P
• 分子量: 394.321
• InChiKey: LWPWSKGHHNQNCC-MFHOCJEASA-N

反应信息

• 作为反应物：
  描述：

  2',3'-dideoxy-E-5-styryluridine 5'-monophosphate 在 palladium on activated charcoal 氢气 、 三丁基焦磷酸铵 、 N,N'-羰基二咪唑 作用下， 以 水 为溶剂， 反应 40.0h， 生成 2',3'-dideoxy-5-(2-phenethyl)uridine 5'-triphosphate
  参考文献：
  名称：

  Synthetic Nucleosides and Nucleotides. XXXI.¹Inhibitory Effects of 2′-Deoxy-5-styryluridine 5′-Triphosphate Analogues on Retroviral Reverse Transcriptases and Higher Eukaryotic DNA Polymerases

  摘要：

  Some new 5'-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3'-dideoxyUTP analogues.

  DOI：

  10.1080/15257779408012149
• 作为产物：
  描述：

  2',3'-dideoxy-E-5-styryluridine 在 磷酸三乙酯 、 三氯氧磷 作用下， 反应 15.0h， 以75%的产率得到2',3'-dideoxy-E-5-styryluridine 5'-monophosphate
  参考文献：
  名称：

  Synthetic Nucleosides and Nucleotides. XXXI.¹Inhibitory Effects of 2′-Deoxy-5-styryluridine 5′-Triphosphate Analogues on Retroviral Reverse Transcriptases and Higher Eukaryotic DNA Polymerases

  摘要：

  Some new 5'-triphosphate derivatives of 2',3'-dideoxy-5-styryluridine analogues have been synthesized and examined for their inhibitory effects on retroviral reverse transcriptases and eukaryotic DNA polymerases. We describe here the mode of inhibition and the influence of the substituent at the 5-position of uracil ring of 2',3'-dideoxyUTP analogues.

  DOI：

  10.1080/15257779408012149