tert-butyl 2-allyl-2-ethylhydrazinecarboxylate | 1044792-44-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tert-butyl 2-allyl-2-ethylhydrazinecarboxylate
• CAS: 1044792-44-0
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.281
• InChiKey: ZRQYOEZSBCZPPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.93
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  41.57
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-溴丙烯 、 2-甲基-2-丙基2-乙基肼羧酸酯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以65%的产率得到tert-butyl 2-allyl-2-ethylhydrazinecarboxylate
  参考文献：
  名称：

  Effective strategy for the systematic synthesis of hydrazine derivatives

  摘要：

  A new and efficient strategy for the systematic synthesis of hydrazine derivatives is reported. It allows the synthesis of up to tetrasubstituted hydrazine derivatives with minimal number of steps using only one protecting group or without any of them at all. Simple and readily available starting materials such as hydrazine hydrate or phenylhydrazine can be used. A variety of substrates were used to investigate scope and limitations of this strategy, additionally one full synthetic sequence was performed. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.04.096

文献信息

• Pd-Catalyzed Regioselective Allylation of Mono- and Disubstituted Hydrazines
  作者：Svetlana Tšupova、Uno Mäeorg

  DOI：10.1021/ol4014798

  日期：2013.7.5

  Palladium-catalyzed allylation of hydrazines using allyl alcohols is reported. This highly efficient protocol furnishes monoallylated hydrazines selectively, in 27–99% yields. Following an optimization of the reaction conditions and of the Pd-ligands, the allylations of both mono- and disubstituted hydrazines were investigated, as well as the effects of C2-substitution on the allylating agent. Of particular

  报道了使用烯丙醇的钯催化的肼的肼烯丙基化。这种高效的方法选择性地提供了单烯丙基化肼，收率为27–99％。优化反应条件和Pd-配体后，研究了单取代和二取代肼的烯丙基化以及C2-取代对烯丙基化剂的影响。特别令人感兴趣的是，证明了一种用于单取代的肼的选择性单烯丙基化的新方法。