BRD-3918 | 1565827-89-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: BRD-3918
• 英文别名: N-[(2R,4aS,12aR)-2-[2-(2,3-dihydro-1H-inden-2-ylamino)-2-oxoethyl]-5-methyl-6-oxo-2,3,4,4a,12,12a-hexahydropyrano[2,3-c][1,5]benzoxazocin-8-yl]-4-(trifluoromethyl)benzamide
• CAS: 1565827-89-5
• 化学式: C₃₃H₃₂F₃N₃O₅
• 分子量: 607.629
• InChiKey: CCWJWXJNOLFYBD-WBJKNQCFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  44
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM<br/>[FR] MODULATEURS DE MÉTABOLISME DES LIPOPROTÉINES HÉPATIQUES
  申请人：BROAD INST INC

  公开号：WO2016100711A1

  公开（公告）日：2016-06-23

  The invention relates to compounds for modulating hepatic cholesterol metabolism. The invention includes methods of making and using the compounds. These compounds or pharmaceutically acceptable salts thereof are useful for treating, preventing, and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in a human or animal.

  本发明涉及用于调节肝胆固醇代谢的化合物。本发明包括制备和使用这些化合物的方法。这些化合物或其药学上可接受的盐对于治疗、预防和/或减轻人或动物的胆固醇相关疾病、心血管疾病和/或肝脏疾病非常有用。
• Modulators of Hepatic Lipoprotein Metabolism
  申请人：The Broad Institute, Inc.

  公开号：US20150216855A1

  公开（公告）日：2015-08-06

  The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.
• US9526720B2
  申请人：——

  公开号：US9526720B2

  公开（公告）日：2016-12-27