phenylborane, compound with triethylamine (1:1) | 857404-98-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenylborane, compound with triethylamine (1:1)
• 英文别名: phenylborane; compound with triethylamine (1:1)；phenyl-borane; compound with triethylamine；Phenyl-boran; Verbindung mit Triaethylamin；Triaethylamin-phenylboran；Tiaethylamin-Phenylboran
• CAS: 857404-98-9
• 化学式: C₆H₇B*C₆H₁₅N
• 分子量: 191.124
• InChiKey: JTYYHOZSXGGEHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  14.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.24
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N,N-二烯丙基-s-丁基胺 、 phenylborane, compound with triethylamine (1:1) 生成 1-sec-butyl-5-phenyl-[1,5]azaborocane
  参考文献：
  名称：

  The Synthesis of Substituted 1,2-Azaborolidines and 1-Aza-5-borabicyclo[3.3.0]octanes¹

  摘要：

  DOI：

  10.1021/jo01023a049
• 作为产物：
  描述：

  Cp2ZrCl((μ-H)2BHPh)2*0.5toluene 、 三乙胺 以 甲苯 为溶剂， 以72.6%的产率得到Cp2ZrH((μ-H)2BHPh)
  参考文献：
  名称：

  锆茂和钛茂相的三氢硼酸苯酯配合物的合成，结构和性质,锆茂和钛茂相的三氢硼酸苯酯配合物的合成，结构和性质

  摘要：

  由Cp反应制得苯基三氢硼酸酯配合物Cp 2 ZrCl {（μ-H）2 BHPh} 1和Cp 2 Zr {（μ-H）2 BHPh} 2  ·（1/2甲苯）2。2的ZrCl 2与的LiBH的一个和两个摩尔3 pH值。在中Zr-H-B键2是稳定的真空下在100℃下不分解显著小时。已经提出了这种强相互作用的感应作用。与路易斯碱N（C 2 H 5）3反应生成（C 2 H5）3 N·BH 2 Ph和氢化锆化合物Cp 2 ZrH {（μ-H）2 BHPh}，3。化合物3也可以由Cp 2 ZrHCl与LiBH 3 Ph反应制得。1与路易斯酸B（C 6 F 5）3的反应取决于溶剂，复分解产物Cp 2 ZrCl {（μ-H）在甲苯溶液中形成2 B（C 6 F 5）2 }，4，而离子络合物[Cp 2从醚溶液中分离出ZrCl（OEt 2）] [HB（C 6 F 5）3 ]，5。钛茂二氯化物Cp 2 TiCl 2与LiBH

  DOI：

  10.1016/j.jorganchem.2004.09.026

文献信息

• Basil, John D.; Aradi, Allen A.; Bhattacharyya, Nripendra K., Inorganic Chemistry, 1990, vol. 29, # 6, p. 1260 - 1270
  作者：Basil, John D.、Aradi, Allen A.、Bhattacharyya, Nripendra K.、Rath, Nigam P.、Eigenbrot, Charles、Fehlner, Thomas P.

  DOI：——

  日期：——
• In vitro anti-glioblastoma activity of L-valine derived boroxazolidones
  作者：Anisha Viswanathan、Giulia Sebastianelli、Kenna Brown、Jenna Raunio、Vili Sipilä、Olli Yli-Harja、Nuno R. Candeias、Meenakshisundaram Kandhavelu

  DOI：10.1016/j.ejphar.2019.04.020

  日期：2019.7

  In the present study, a series of L-valine derived boroxazolidones, previously synthesized and reported to have residual activity in a human epithelial cell line, have been evaluated in vitro for their anti-glioblastoma activity. A boroxazolidone derivative containing 2,4-difluorophenyl moieties (6) was found to have higher cytotoxicity than the standard drug, Temozolomide (TMZ). Compound 6 was found to exhibit dose-dependent growth inhibitory effects with an IC50 of 49 mu M and 53 mu M for LN229 and SNB19 cells, respectively. Additionally, 6 was assessed for its role in apoptosis, caspase 3/7 activation and oxidative stress in SNB19 and LN229 cells. SNB19 cells treated with 6 showed 45.3% apoptosis in the population, while TMZ had 24.7%. In LN229 cells, the percentage of apoptotic cells treated with compound 6 and TMZ were the same. Both 6 and TMZ induced apoptosis through the activation of caspase 3/7 in SNB19 and LN229 cells. Interestingly, 6 exhibited a higher effectivity in promoting reactive oxygen species production in LN229, while it was 6-fold less in SNB19. Boroxazolidone-treated GBM cell lines increased reactive oxygen species production, suggesting that such species may be interlinked with the observed programmed cell death. Additionally, the treatment of both GBM cell lines with 6 led to G2/M phase arrest. The magnitude of anti-GBM effect of 6 is significantly higher than the known chemotherapeutic agent TMZ. This work further demonstrates the anticancer properties of L-valine derived boroxazolidones, adding another potential derivative to the collection of promising chemotherapeutic agents for GBM treatment.
• Synthesis of a Novel Heterobicycloalkane Containing Boron and Phosphorus
  作者：George B. Butler、Gary L. Statton

  DOI：10.1021/ja01076a091

  日期：1964.11