1-amino-1-(2-pyridyl)guanidine | 125730-04-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-amino-1-(2-pyridyl)guanidine
• 英文别名: 1-Amino-1-pyridin-2-ylguanidine
• CAS: 125730-04-3
• 化学式: C₆H₉N₅
• 分子量: 151.171
• InChiKey: SIZDXOFVZRLYBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Aminoguanidine derivatives
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0339496A2

  公开（公告）日：1989-11-02

  A aminoguanidine derivatives of the general formula: (wherein, R1b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s), cycloalkyl group of from 5 to 7 carbon atoms or carbocyclic or heterocyclic ring unsubstituted or substituted by from one to three halogen atom(s), alkyl group(s) of from 1 to 4 carbon atom(s), alkoxy group(s) of from 1 to 4 carbon atom(s) or nitro group, Xb represents a bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, R2b represents a hydrogen atom, alkyl group of from 1 to 6 carbon atom(s) or phenyl group, R3b represents a hydrogen atom, phenyl group, alkyl group of from 1 to 4 carbon atom(s), phenylalkyl group of from 7 to 10 carbon atoms or pyridyl group represents a heterocyclic ring, which contains nitrogen atom or one nitrogen and one oxygen atom, of from 3 to 10 carbon atoms unsubstituted or substituted by a hydroxy group. With the proviso that the compounds wherein R2b represents a hydrogen atom, -Xb-R1b represents a hydrogen atom, methyl group, ethyl group or phenyl group and R3b represents a hydrogen atom or methyl group, are excluded.) or acid addition salt thereof possess inhibitory activity on Maillard reaciton, and therefore is useful for treating and/or prevention of several diabetic complications and diseases induced by aging.

  通式如下的氨基胍衍生物 (其中，R1b 代表氢原子、1 至 6 个碳原子的烷基、5 至 7 个碳原子的环烷基或未被取代或被 1 至 3 个卤素原子、1 至 4 个碳原子的烷基、1 至 4 个碳原子的烷氧基或硝基取代的碳环或杂环，Xb 代表键、1 至 4 个碳原子的亚烷基或 2 至 4 个碳原子的亚烯基、 R2b 代表氢原子、1-6 个碳原子的烷基或苯基、 R3b 代表氢原子、苯基、1 至 4 个碳原子的烷基、7 至 10 个碳原子的苯基烷基或吡啶基 代表含有氮原子或一个氮原子和一个氧原子的杂环，其碳原子数为 3 至 10 个，未被羟基取代或被羟基取代。 但 R2b 代表氢原子，-Xb-R1b 代表氢原子、甲基、乙基或苯基，R3b 代表氢原子或甲基的化合物除外）或其酸加成盐具有抑制 Maillard 反应的活性，因此可用于治疗和/或预防多种糖尿病并发症和衰老引起的疾病。