硫酸碘苄胍EP标准品 | 87862-25-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 硫酸碘苄胍EP标准品
• 英文名称: 3-Iodobenzylguanidine hemisulfate
• 英文别名: diaminomethylidene-[(3-iodophenyl)methyl]azanium;sulfate
• CAS: 87862-25-7
• 化学式: C16H22I2N6O4S
• 分子量: 648.3
• InChiKey: XNACDNPGABUBFR-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMSO：2mg/mL； DMSO:PBS (pH 7.2) (1:4)：0.2 mg/mL

计算性质

• 辛醇/水分配系数(LogP)：
  -0.84
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  222
• 氢给体数：
  6
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物，干扰细胞单核(ADP-核糖基化)。

体外研究

Iobenguane sulfate (MIBG sulfate) (2-20 μg/ml; 72 hours) inhibits cell growth in a panel of human and mouse leukemia, fibrosarcoma, melanoma, and neuroblastoma cell lines.
Iobenguane sulfate (MIBG sulfate) is a potent affector of endogenous mono(ADP-ribosyl) transferases of turkey and human erythrocyte membranes, exerting its effect in the μM concentration range.

Cell Proliferation Assay

Cell Line:	3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, CHP212 cells
Concentration:	2, 20μg/ml
Incubation Time:	72 hours
Result:	Inhibits 3T3, 3T3-Tl3, BHK, Py-BHK, K562, L1210, RIF1, M5A, B16, LAN-1, N1E115, and CHP212 cells growth.

体内研究

Iobenguane sulfate (MIBG hemisulfate) (20 mg/kg; i.p.; daily on days 3-6) shows antitumor activity.
The survival of male strain AF mice inoculates with N1E115 neuroblastoma and treats according to NIH protocols for new drug testing with 9 daily injections of Iobenguane sulfate (40 mg/kg), Marking prolongation of sugvival but no cures were observed.
Iobenguane sulfate testes for its toxicity on male strain AF (N1Ell5) mice with 5 daily injections. At 50 mg/kg body weight, all animals died after 1-4 doses and 4/16 animals died on a schedule of 44 mg/kg.

Animal Model:	DBA/2 (L1210)) mice
Dosage:	i.p.; daily on days 3-6
Administration:	20 mg/kg
Result:	Considerable prolongation of survival and some cures were obtained.