1-Isopropyl-3-phenyl-guanidin | 17813-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Isopropyl-3-phenyl-guanidin
• 英文别名: 1-Phenyl-2-propan-2-ylguanidine
• CAS: 17813-42-2
• 化学式: C₁₀H₁₅N₃
• 分子量: 177.249
• InChiKey: UTYGSZTZAJVMKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Benzimidazole Derivatives and Preparation Process and Pharmaceutical Uses Thereof
  申请人：WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD

  公开号：US20170022188A1

  公开（公告）日：2017-01-26

  The invention belongs to the technical field of pharmaceutical chemistry, and particularly pertains to benzimidazole derivatives, and preparation process and pharmaceutical uses thereof. Benzimidazole derivatives include Ligustrazine and NO donor derivatives. The kind of the compounds can rapidly release Ligustrazine or No in vivo, so that they can produce effective synergetic effects with Azilsartan, to enhance the anti-hypertension effect, and reduce adverse effects, and the released Ligustrazine can produce ideal protection to patients' livers and kidneys, thereby filling blanks in the prior art

  这项发明属于药物化学技术领域，特别涉及苯并咪唑衍生物及其制备工艺和药用用途。苯并咪唑衍生物包括川芎素和NO供体衍生物。这些化合物可以在体内快速释放川芎素或NO，从而能够与阿利沙坦产生有效的协同作用，增强抗高血压效果，减少不良反应，释放的川芎素可以对患者的肝脏和肾脏产生理想的保护作用，从而填补了先前技术领域的空白。
• Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors
  申请人：Kautz Ulrich

  公开号：US20070167482A1

  公开（公告）日：2007-07-19

  The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.

  某种公式（1）的化合物，其中R1，R2，R3，R31，R4，R5，R6和R7的含义如描述中所给出的，是新颖有效的PDE4抑制剂。
• Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiestrase (PDE) 4 inhibitors
  申请人：Kautz Ulrich

  公开号：US20100035913A1

  公开（公告）日：2010-02-11

  The compounds of a certain formula (1), in which R1, R2, R3, R31, R4, R5, R6 and R7 have the meanings as given in the description, are novel effective PDE4 inhibitors.

  某种化学式(1)的化合物，其中R1、R2、R3、R31、R4、R5、R6和R7的含义如描述中所述，是新的有效PDE4抑制剂。
• Potassium salt of benzimidazole compound and preparation method therefor, composition and application thereof
  申请人：WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.

  公开号：US11008311B2

  公开（公告）日：2021-05-18

  The preparation method for the compound, composition and application thereof in preparing an angiotensin II receptor antagonist or application in preparing medicine for preventing and/or treating hypertension, chronic heart failure and diabetic nephropathy. After entering a human body, when releasing azilsartan, the compound releases hydroxyligustrazine or NO at the same time, thus generating a synergistic effect with azilsartan. The compound therefore has stronger and longer blood pressure lowering effect, more obvious and longer lasting heart rate lowering effect and high safety, and achieves ideal protective effect for heart and kidney functions.

  该化合物的制备方法、组合物及其在制备血管紧张素 II 受体拮抗剂中的应用或在制备预防和/或治疗高血压、慢性心力衰竭和糖尿病肾病的药物中的应用。该化合物进入人体后，在释放阿齐沙坦时，同时释放羟基古司他嗪或 NO，从而与阿齐沙坦产生协同作用。因此，该复方制剂降压效果更强、更持久，降心率效果更明显、更持久，安全性高，对心脏和肾脏功能有理想的保护作用。
• CATALYSTS AND METHODS FOR POLYMER SYNTHESIS
  申请人：Saudi Aramco Technologies Company

  公开号：US20180179242A1

  公开（公告）日：2018-06-28

  The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are methods of using such metal complexes in the synthesis of polymers. According to one aspect, the present invention provides metal complexes comprising an activating species with co-catalytic activity tethered to a multidentate ligand that is coordinated to the active metal center of the complex.