(2-chloro-pyrimidin-4-yl)(2-pyridin-2-yl-ethyl)carbamic acid 2,6-dimethylphenyl ester | 837421-84-8

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: (2-chloro-pyrimidin-4-yl)(2-pyridin-2-yl-ethyl)carbamic acid 2,6-dimethylphenyl ester
• 英文别名: (2,6-dimethylphenyl) N-(2-chloropyrimidin-4-yl)-N-(2-pyridin-2-ylethyl)carbamate
• CAS: 837421-84-8
• 化学式: C₂₀H₁₉ClN₄O₂
• 分子量: 382.849
• InChiKey: GCASZVBMUWAGKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  68.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES<br/>[FR] 2-AMINOPYRIMIDINE ET 2-AMINOPYRIDINE-4-CARBAMATES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES AUTO-IMMUNES
  申请人：AMGEN INC

  公开号：WO2005009978A1

  公开（公告）日：2005-02-03

  The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula (1) and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.

  本发明涉及具有通用式（1）的嘧啶或吡啶羰酸酯化合物及其药用可接受的盐或衍生物。还包括治疗各种疾病和症状的方法，包括炎症、抑制T细胞激活和增殖、关节炎、器官移植、缺血或再灌注损伤、心肌梗死、中风、多发性硬化、炎症性肠病、克罗恩病、狼疮、过敏、1型糖尿病、牛皮癣、皮炎、桥本氏甲状腺炎、干燥综合征、自身免疫性甲状腺功能亢进症、艾迪生病、自身免疫疾病、肾小球肾炎、过敏性疾病、哮喘、花粉症、湿疹、癌症、结肠癌、胸腺瘤等，在哺乳动物中的方法，包括给予通用式I的化合物的治疗有效量，或如上所述的盐或衍生物形式。
• Substituted heterocyclic compounds and methods of use
  申请人：Buchanan L. John

  公开号：US20050026914A1

  公开（公告）日：2005-02-03

  The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.

  本发明涉及具有一般式I的嘧啶或吡啶氨基甲酸酯化合物及其药学上可接受的盐或衍生物。还包括治疗各种疾病和病况的方法，包括炎症，抑制T细胞激活和增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗死，中风，多发性硬化症，炎症性肠病，克罗恩病，狼疮，过敏，1型糖尿病，牛皮癣，皮炎，桥本甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进症，亚当逊病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘，花粉症，湿疹，癌症，结肠癌，胸腺瘤等，在哺乳动物中的方法，包括给予一种式I化合物的治疗有效量，或如上所述的其盐或衍生物形式。
• 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES
  申请人：AMGEN INC.

  公开号：EP1654238A1

  公开（公告）日：2006-05-10
• US7442698B2
  申请人：——

  公开号：US7442698B2

  公开（公告）日：2008-10-28