N-Methyl-2-aminoheptafluoronaphthalene | 370556-50-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-Methyl-2-aminoheptafluoronaphthalene
• 英文别名: 1,3,4,5,6,7,8-heptafluoro-N-methylnaphthalen-2-amine
• CAS: 370556-50-6
• 化学式: C₁₁H₄F₇N
• 分子量: 283.148
• InChiKey: QUMHAVAJAAHPIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-Methyl-2-aminoheptafluoronaphthalene 在 盐酸 、 sodium nitrite 作用下， 反应 2.0h， 以63%的产率得到N-nitroso-N-methyl-2-aminoheptafluoronaphthalene
  参考文献：
  名称：

  Polyfluorinated arylnitrosamines

  摘要：

  N-Methyl-, N-n-butyl-, N-t-butylperfluoroarylamines undergo nitrosation with nitrous acid to give the corresponding N-nitroso derivatives. Perfluoroaryl groups were selected from the benzene, indane, biphenyl, naphthalene and pyridine series. According to H-1 and F-19 NMR spectra, N-nitroso-N-methyl derivatives of polyfluoroarenes, consist of E and Z isomers with the former prevailing. The more bulky n-butyl group promotes an increase in the formation of Z isomers. Only Z isomers have been obtained from N-t-butyl derivatives of perfluorinated 4-toluidine and 4-aminopyridine. The structure of the Z isomer of N-nitroso-N-methylperfluoro-4-toluidine is confirmed by X-ray data. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00567-x
• 作为产物：
  描述：

  八氟萘 、 甲胺 以 水 、 异丙醇 为溶剂， 反应 216.0h， 以92%的产率得到N-Methyl-2-aminoheptafluoronaphthalene
  参考文献：
  名称：

  Polyfluorinated arylnitramines

  摘要：

  N-methyl- and N-butylperfluoroarylamines are transformed by HNO3 into N-nitro-N-methyl- and N-nitro-N-butylperfluoroarylamines. These reactions were used to synthesise N-nitro-N-methylpentafluoroaniline and its p-CF3. -CN, -C6F5 substituted derivatives, N-nitro-N-methylperfluoro-2,4-xylidine, N-nitro-N-methyl-4-aminotetrafluoropyridine N-nitro-N-methyl 5-aminoperfluoroindane, N-nitro-N-methyl-2- aminoheptafluoronaphthalene. 4,4 ' -bis(N-nitro-N- merhylamino)octafluorobiphenyl from 4,4 ' -bis(N-methylamino)octafluorobiphenyl, N-nitro-N-n-butylpentafluoroaniline, N-nitro-N-n-butylperfluoro-p-toluidine, N-nitro-N-n-butyl-4-aminotetrafluoropyridine and N-nitro-bis( perfluoro-p-tolyl)amine. Tetrafluoro-p-benzoquinone and heptafluoro-p-toluquinol were obtained from N-methylpentafluoroanilinz and N-methylperfluoro-p-toluidine, respectively, under the action of a mixture of HNO3 and H2SO4 The X-ray crystal structure of N-nitro-N-methylperfluoro-p-toluidine was determined. (C) 2001 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-1139(01)00367-0