GW473178E methyl benzene sulphonic acid | 263553-33-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: GW473178E methyl benzene sulphonic acid
• 英文别名: N-ethyl-3-methyl-N-propan-2-yl-5-[(2S)-2-(pyridin-4-ylamino)propoxy]benzamide;4-methylbenzenesulfonic acid
• CAS: 263553-33-9
• 化学式: C28H37N3O5S
• 分子量: 527.7
• InChiKey: DGYJWEFQVJQFIA-LMOVPXPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Benzamide derivatives as thrombin inhibitors
  申请人：——

  公开号：US20020169189A1

  公开（公告）日：2002-11-14

  There are provided according to the invention novel compounds of formula (I) 1 wherein R 1 represents C 1-4 alkyl or C 3-8 cycloalkyl, R 2 represents C 1-4 alkyl or C 3-4 alkenyl, R 3 represents hydrogen, C 1-3 alkyl or halogen, and R 4 represents C 1-6 alkyl, processes for preparing them, pharmaceutical formulations containing them and their use in therapy particularly as thrombin inhibitors.

  根据本发明提供了新型化合物的公式（I）1，其中R1代表C1-4烷基或C3-8环烷基，R2代表C1-4烷基或C3-4烯基，R3代表氢、C1-3烷基或卤素，R4代表C1-6烷基，制备它们的过程，包含它们的制药配方以及它们在治疗中的用途，特别是作为凝血酶抑制剂。
• BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS
  申请人：GLAXO GROUP LIMITED

  公开号：EP1117644A1

  公开（公告）日：2001-07-25
• US6441008B1
  申请人：——

  公开号：US6441008B1

  公开（公告）日：2002-08-27
• US6670381B2
  申请人：——

  公开号：US6670381B2

  公开（公告）日：2003-12-30
• [EN] BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS<br/>[FR] DERIVES DE BENZAMIDE INHIBITEURS DE LA THROMBINE
  申请人：GLAXO GROUP LTD

  公开号：WO2000020394A1

  公开（公告）日：2000-04-13

  There are provided according to the invention novel compounds of formula (I), wherein R1 represents C¿1-4?alkyl or C3-8cycloalkyl, R?2¿ represents C¿1-4?alkyl or C3-4alkenyl, R?3¿ represents hydrogen, C¿1-3?alkyl or halogen, and R?4¿ represents C¿1-6?alkyl, processes for preparing them, pharmaceutical formulations containing them and their use in therapy particularly as thrombin inhibitors.