N-(3-(3-((2-(dimethylamino)ethyl)(methyl)amino)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)propane-1-sulfonamide | 1425486-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-(3-((2-(dimethylamino)ethyl)(methyl)amino)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)propane-1-sulfonamide
• 英文别名: N-(3-(3-((2-(dimethylamino)ethyl)(methyl)amino)quinoxaline-6-carbonyl)-2,4,5-trifluorophenyl)propane-1-sulfonamid；N-(3-(3-((2-(Dimethylamino)ethyl)(methyl)amino)quinoxalin-6-carbonyl)-2,4,5-trifluorophenyl)propan-1-sulfonamide；N-[3-[3-[2-(dimethylamino)ethyl-methylamino]quinoxaline-6-carbonyl]-2,4,5-trifluorophenyl]propane-1-sulfonamide
• CAS: 1425486-06-1
• 化学式: C₂₃H₂₆F₃N₅O₃S
• 分子量: 509.552
• InChiKey: GVXIOXSQUUDGEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• Certain Chemical Entities, Compositions, and Methods
  申请人：Zhu Yong-Liang

  公开号：US20130053384A1

  公开（公告）日：2013-02-28

  Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.

  描述了一种激酶抑制剂、制药组合物和使用这些化学实体的方法，例如用于治疗癌症。
• Benzenesulfonamide derivatives of quinoxaline, pharmaceutical compositions thereof, and their use in methods for treating cancer
  申请人：NeuPharma, Inc.

  公开号：US10137125B2

  公开（公告）日：2018-11-27

  Benzenesulfonamide derivatives of quinoxaline that are kinase inhibitors, pharmaceutical compositions and methods of using these derivatives, e.g., for treatment of cancer are described.

  描述了作为激酶抑制剂的喹喔啉的苯磺酰胺衍生物、药物组合物和使用这些衍生物（例如用于治疗癌症）的方法。
• CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
  申请人：Neupharma, Inc.

  公开号：EP2747767A1

  公开（公告）日：2014-07-02
• BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER
  申请人：NEUPHARMA, INC.

  公开号：US20160303118A1

  公开（公告）日：2016-10-20

  Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of using these chemical entities, e.g., for treatment of cancer are described.
• US9295671B2
  申请人：——

  公开号：US9295671B2

  公开（公告）日：2016-03-29