4-(2-Hydroxyethyl)-N-(4-methylphenyl)benzamide | 128829-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-Hydroxyethyl)-N-(4-methylphenyl)benzamide
• CAS: 128829-32-3
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.31
• InChiKey: XLWYTZRXFFYJMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• 13-Substituted milbemycin derivatives, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0357460A2

  公开（公告）日：1990-03-07

  Compounds of formula (I):: [in which: R¹ and R² are hydrogen, halogen, cyano, nitro, alkyl, substituted alkyl, alkoxy, alkoxyalkoxy, -(CH₂)nNHR⁹, (where n is 0, 1 or 2, and R⁹ is hydrogen or alkyl), -(CH₂)nNR⁹C(=O)R⁶ (where R⁶ is hydrogen, alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, aryl, or heterocyclic), -(CH₂)nNR⁹COCOR⁶, -(CH₂)nR⁹COCOOR⁷ (where R⁷ is alkyl, cycloalkyl or aralkyl), -(CH₂)nNR⁹CHR⁶NHCOR⁶, -(CH₂)nNR⁹CHR⁶NHCONHR⁶, -(CH₂)nNR⁹CHR⁶NHCOOR⁷, -(CH₂)nNR⁹C(=Y)YR⁶ (where each Y is oxygen or sulphur), -(CH₂)nNR⁹C(=Y)NR6′R6′ (where each R6′ is R⁶, or the two and the nitrogen form a heterocyclic group), -(CH₂)nNR⁹C(=Y)NR6˝R6˝ (where each R6˝ is R⁶, or any two of R6˝ and its nitrogen forms a heterocyclic group), -(CH₂)nNR⁹C(=Y)NR⁶NHZ (where Z is -COOR⁷, -COR⁶ or -SO₂R⁶), -(CH₂)nNR⁹C(=NR¹⁰)NHR¹⁰ (where each R¹⁰ is R⁶, cyano, nitro, -COOR⁷ or -COR⁶), -(CH₂)nNR⁹C(=NR¹⁰)R⁶, -(CH₂)nNR⁹SOmR⁶ (where m is 1 or 2), -CONHR⁶, or -COOR⁷), R³ and R⁴ are each hydrogen, alkyl or alkoxy; R⁵ is methyl, ethyl, isopropyl or sec-butyl; and X is hydroxy, alkanoyloxy, substituted alkanoyloxy or hydroxyimino] and its salts have valuable acaricidal, insecticidal and anthelmintic activities.

  式(I)化合物 其中R¹ 和 R² 是氢、卤素、氰基、硝基、烷基、取代烷基、烷氧基、烷氧基烷氧基、-(CH₂)nNHR⁹，（其中 n 是 0、1 或 2、-(CH₂)nNR↪No_2079COCOR⁶，-(CH₂)nR↪No_2079COCOOR⁷（其中 R⁷ 是烷基、环烷基或芳烷基）、-(CH₂)nNR↪No_2079CHR⁶NHCOR⁶，-(CH₂)nNR↪No_2079CHR⁶NHCONHR⁶，-(CH₂)nNR↪No_2079CHR⁶NHCOOR⁷，-(CH₂)nNR↪No_2079C(=Y)YR⁶（其中每个 Y 为氧或硫）、-(CH₂)nNR⁹C(=Y)NR6′R6′（其中每个 R6′都是 R⁶，或两者与氮形成杂环基团），-(CH₂)nNR⁹C(=Y)NR6˝R6˝（其中每个 R6˝都是 R⁶、或任意两个 R6˝ 及其氮构成杂环基团）、-(CH₂)nNR↪No_2079C(=Y)NR⁶NHZ（其中 Z 为 -COR⁷、-⁶）、-(CH₂)nNR⁹C(=NR¹⁰)NHR¹⁰（其中每个 R¹⁰ 是 R⁶、氰基、硝基、-COOR⁷ 或 -COR⁶）、-(CH₂)nNR⁹C(＝NR¹⁰)R⁶、-(CH₂)nNR⁹SOmR⁶（其中 m 为 1 或 2）、-CONHR⁶ 或 -COR⁷），R³ 和 R⁴ 各自为氢、烷基或烷氧基；R⁵ 是甲基、乙基、异丙基或仲丁基；X 是羟基、烷酰氧基、取代的烷酰氧基或羟基亚氨基] 及其盐类具有重要的杀螨、杀虫和驱虫活性。
• US5428034A
  申请人：——

  公开号：US5428034A

  公开（公告）日：1995-06-27
• US5686484A
  申请人：——

  公开号：US5686484A

  公开（公告）日：1997-11-11