N-[3,5-Bis(trifluoromethyl)phenyl]-2,6-dichlorobenzene-1-sulfonamide | 646040-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3,5-Bis(trifluoromethyl)phenyl]-2,6-dichlorobenzene-1-sulfonamide
• 英文别名: N-[3,5-bis(trifluoromethyl)phenyl]-2,6-dichlorobenzenesulfonamide
• CAS: 646040-70-2
• 化学式: C₁₄H₇Cl₂F₆NO₂S
• 分子量: 438.2
• InChiKey: MGPKKGPZGMSPSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• SUBSTITUTED BIARYL SULFONAMIDES AND THE USE THEREOF
  申请人：NOVOMEDIX, LLC

  公开号：US20140155477A1

  公开（公告）日：2014-06-05

  Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

  本文提供了替代的双芳基磺酰胺化合物、包含该化合物的药物组合物、其制备方法以及使用方法。这些化合物可用于治疗、预防和/或改善各种疾病，包括癌症和增殖性疾病。在一种实施例中，本文提供的化合物调节蛋白质翻译的启动。在一种实施例中，本文提供的化合物与手术、放射治疗、免疫治疗和/或一个或多个其他抗癌药物结合使用，用于治疗、预防和/或改善癌症和增殖性疾病。
• [EN] BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY<br/>[FR] COMPOSES DE BISARYLSULFONAMIDE ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
  申请人：CYCLACEL LTD

  公开号：WO2004005278A1

  公开（公告）日：2004-01-15

  The present invention relates to the use of bisarylsulfonamide compounds of formula (I) wherein W is a CI-5 branched or unbranched alkyl group or a C2-5 alkenyl group; nis0or1; R1 is H, a C, 1-8 branched or unbranched alkyl group, a C2-8 alkenyl group, or an aryl or aralkyl group; Ar1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula (I), pharmaceutical compositions thereof, and an assay for determining binding to HDM2.

  本发明涉及使用公式（I）中的双芳基磺酰胺化合物，其中W是CI-5支链或直链烷基或C2-5烯基基团；n为0或1；R1为H，C1-8支链或直链烷基，C2-8烯基基团，或芳基或芳基烷基团；Ar1为取代噻吩基，呋喃基，吡咯基，咪唑硫唑基，噻唑基，吡啶基或苯基；Ar2为取代苯基，吲哚基或苯并咪唑基团，在制备用于治疗增殖性疾病的药物方面。本发明的其他方面涉及公式（I）的化合物，其制药组合物以及用于确定与HDM2结合的测定方法。
• Substituted biaryl sulfonamides and the use thereof
  申请人：NovoMedix, LLC

  公开号：US10040757B2

  公开（公告）日：2018-08-07

  Provided herein are substituted biaryl sulfonamide compounds, pharmaceutical compositions comprising the compounds, methods of their preparation, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or amelioration of various disorders, including cancer and proliferative disorders. In one embodiment, the compounds provided herein modulate initiation of protein translation. In one embodiment, the compounds provided herein are used in combination with surgery, radiation therapy, immuno therapy and/or one or more additional anticancer drugs for the treatment, prevention, and/or amelioration of cancer and proliferative disorders.

  本文提供了取代的双芳基磺酰胺化合物、包含这些化合物的药物组合物、其制备方法和使用方法。本文提供的化合物可用于治疗、预防和/或改善各种疾病，包括癌症和增殖性疾病。在一个实施方案中，本文提供的化合物可调节蛋白质翻译的启动。在一个实施方案中，本文提供的化合物与手术、放射治疗、免疫治疗和/或一种或多种额外的抗癌药物联合使用，用于治疗、预防和/或改善癌症和增殖性疾病。
• Bisarylsulfonamide compounds and their use in cancer therapy
  申请人：Wang Shudong

  公开号：US20050215548A1

  公开（公告）日：2005-09-29

  The present invention relates to the use of bisarylsulfonamide compounds of formula I wherein W is a C 1-5 branched or unbranched alkyl group or a C 2-5 alkenyl group; n is 0 or 1; R 1 is H, a C 1-8 branched or unbranched alkyl group, a C 2-8 alkenyl group, or an aryl or aralkyl group; Ar 1 is a substituted thienyl, furyl, pyrrolyl, imidazothiazolyl, thiazolyl, pyridyl or phenyl group; and Ar 2 is a substituted phenyl, indolyl or benzoimidazolyl group; in the preparation of a medicament for treating proliferative disorders. Further aspects of the invention relate to compounds of formula I, pharmaceutical compositions thereof, and an assay for determining binding to HDM2.

  本发明涉及式 I 双芳磺酰胺化合物的用途 其中 W 是 C 1-5 支链或未支链烷基或 C 2-5 烯基；n 为 0 或 1； R 1 是 H、C 1-8 支链或未支链烷基、C 2-8 烯基、芳基或芳烷基； Ar 1 是取代的噻吩基、呋喃基、吡咯基、咪唑噻唑基、噻唑基、吡啶基或苯基；以及 Ar 2 是取代的苯基、吲哚基或苯并咪唑基；用于制备治疗增生性疾病的药物。本发明的其他方面涉及式 I 的化合物、其药物组合物以及确定与 HDM2 结合的检测方法。
• BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY
  申请人：Cyclacel Limited

  公开号：EP1519932A1

  公开（公告）日：2005-04-06