5'-O-Propionyluridin | 64864-57-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5'-O-Propionyluridin
• 英文别名: [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl propanoate
• CAS: 64864-57-9
• 化学式: C₁₂H₁₆N₂O₇
• 分子量: 300.268
• InChiKey: NRZVONGUHYGRCK-FOBYXSAKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2',3',5'-tri-O-propionyluridine 在 正丁基锂 、 2,2,2-三氟乙醇 作用下， 以 正己烷 为溶剂， 反应 2.0h， 以83%的产率得到5'-O-Propionyluridin
  参考文献：
  名称：

  Selective Removal of the 2‘- and 3‘-O-Acyl Groups from 2‘,3‘,5‘-Tri-O-acylribonucleoside Derivatives with Lithium Trifluoroethoxide¹

  摘要：

  Selective cleavage of O2' and O3' ester groups from ribonucleoside derivatives has been accomplished with Dowex 1 x 2 (CF3CH2O-) in 2,2,2-trifluoroethanol (TFE) or lithium trifluoroethoxide/TFE. Deacylations with Li+ -OCH2CF3/TFE proceed at ambient temperature (or with mild heating) to give the 5'-O-acyl derivatives in superior yields and higher purity than prior approaches for selective O2' and O3' ester deprotection.

  DOI：

  10.1021/jo0600104

文献信息

• USE OF COMPOUNDS FOR THE TREATMENT OF PAIN
  申请人：Akron Molecules AG

  公开号：EP2846788A1

  公开（公告）日：2015-03-18
• [EN] USE OF COMPOUNDS FOR THE TREATMENT OF PAIN<br/>[FR] UTILISATION DE COMPOSÉS POUR LE TRAITEMENT DE LA DOULEUR
  申请人：AKRON MOLECULES GMBH

  公开号：WO2013167743A1

  公开（公告）日：2013-11-14

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
• [EN] BIOMEDICAL DEVICE IMPLANTABLE IN BONE AND/OR CARTILAGINOUS TISSUE, AND CORRESPONDING METHOD TO MANUFACTURE SAID BIOMEDICAL DEVICE<br/>[FR] DISPOSITIF BIOMÉDICAL IMPLANTABLE DANS L'OS ET/OU LE TISSU CARTILAGINEUX, ET PROCÉDÉ CORRESPONDANT POUR FABRIQUER LEDIT DISPOSITIF BIOMÉDICAL
  申请人：GALLI CARLO

  公开号：WO2014128289A1

  公开（公告）日：2014-08-28

  Aptamers for use in coating biomaterials, in particular for example for making biomedical devices which can be implanted in tissue, or tissue implants, corresponding method for coating biomaterials using aptamers and method for making biomedical devices which can be implanted in tissue, or tissue implants.