[Hydroxy(phenoxy)phosphoryl]acetic acid | 62591-82-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Hydroxy(phenoxy)phosphoryl]acetic acid
• 英文别名: 2-[hydroxy(phenoxy)phosphoryl]acetic acid
• CAS: 62591-82-6
• 化学式: C₈H₉O₅P
• 分子量: 216.13
• InChiKey: QBPDCVBBIIKXTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Diamineplatinum complexes with phosphonocarboxylate and substituted phosphonocarboxylate ligands as antitumor agents
  申请人：ENGELHARD CORPORATION

  公开号：EP0290169A2

  公开（公告）日：1988-11-09

  Novel diamineplatinum complexes with phosphonocarboxylate and substituted phosphonocarboxylate ligands are disclosed. These complexes exhibit an antitumor effect and are characterized by low mammalian toxicity.

  本研究公开了具有膦酰羧酸酯和取代膦酰羧酸酯配体的新型二氨铂配合物。这些配合物具有抗肿瘤作用，对哺乳动物毒性低。
• USE OF PYROPHOSPHATE ION ANALOGUES FOR THE TREATMENT OF HPV INFECTION
  申请人：Agencia Pública Empresarial Sanitaria Costa Del Sol

  公开号：EP3241555A1

  公开（公告）日：2017-11-08

  The invention relates to the use of pyrophosphate ion analogues in the production of a drug for the prevention, alleviation or treatment of an HPV infection-related disease. The invention also relates to the pharmaceutical composition, patch or dressing, kit or device and uses.

  本发明涉及焦磷酸离子类似物在生产预防、缓解或治疗人乳头瘤病毒感染相关疾病的药物中的用途。本发明还涉及药物组合物、贴片或敷料、试剂盒或装置及用途。
• NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：EP1030853A1

  公开（公告）日：2000-08-30
• [EN] NOVEL SIGNAL TRANSDUCTION INHIBITORS, COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX INHIBITEURS DE TRANSDUCTION DE SIGNAL, COMPOSITIONS LES CONTENANT
  申请人：ARIAD PHARMACEUTICALS, INC.

  公开号：WO1999024442A1

  公开（公告）日：1999-05-20

  (EN) This invention concerns compounds for inhibiting intracellular signal transduction, especially intracellular signal transduction mediated by one or more molecular interactions involving a phosphotyrosine-containing protein. This invention also relates to pharmaceutical compositions containing the compounds and prophylactic and therapeutic methods involving pharmaceutical and veterinary administration of the compounds. The compounds are of formula (I) as defined herein.(FR) Cette invention concerne des composés destinés à inhiber la transduction de signal intracellulaire, notamment la transduction d'un signal intracellulaire médiée par une ou plusieurs interactions moléculaires impliquant une protéine contenant de la phosphotyrosine. Cette invention concerne également des compositions pharmaceutiques contenant les composés ainsi que des méthodes prophylactiques et thérapeutiques faisant intervenir l'administration pharmaceutique et vétérinaire des composés. Les composés ont la formule (I) telle que ci-définie.