4-Nitrophenyl 6-(2-bromoacetamido)hexanoate | 142717-05-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: 4-Nitrophenyl 6-(2-bromoacetamido)hexanoate
• 英文别名: (4-nitrophenyl) 6-[(2-bromoacetyl)amino]hexanoate
• CAS: 142717-05-3
• 化学式: C14H17BrN2O5
• 分子量: 373.2
• InChiKey: MSYWZRCJRHQKQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Peptide-polysaccharide-protein conjugate vaccines
  申请人：MERCK & CO. INC.

  公开号：EP0468714A2

  公开（公告）日：1992-01-29

  Covalent conjugate immunogens, having Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides covalently bound to the Outer Membrane Protein Complex (OMPC) of Neisseria through a linker which is an anionic polysaccharide (PSA), are useful for inducing anti-peptide immune responses in mammals, for inducing HIV-neutralizing antibodies in mammals, for formulating vaccines to prevent HIV infection or disease, including the Acquired Immune Deficiency Syndrome (AIDS) or for treating humans afflicted with HIV infection or HIV disease, including AIDS.

  人类免疫缺陷病毒（HIV）主要中和决定簇（PND）多肽通过阴离子多糖（PSA）连接体与奈瑟氏菌外膜蛋白质复合物（OMPC）共价结合的共价结合免疫原、可用于诱导哺乳动物的抗肽免疫反应、诱导哺乳动物的 HIV 中和抗体、配制疫苗以预防 HIV 感染或疾病（包括获得性免疫缺陷综合征（艾滋病））或治疗受 HIV 感染或 HIV 疾病（包括艾滋病）困扰的人类。
• Cyclic HIV principal neutralizing determinant peptides
  申请人：MERCK & CO. INC.

  公开号：EP0471453A2

  公开（公告）日：1992-02-19

  Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides, or peptides immunologically equivalent therewith, having the structure : wherein the ring system is formed by ring closure through a stable amide bond, are useful as analytical tools, as reagents in ELISA assays, or as reagents for making covalent conjugate immunogens. Conjugates containing these stable, cyclic peptides are useful for raising mammalian anti-peptide, anti-HIV, or HIV-neutralizing immune responses, and a composition containing such a conjugate may be used as a vaccine to prevent HIV-Disease, including Acquired Immune Deficiency Syndrome, (AIDS), or AIDS related complex, (ARC), or as an immunogen for treating humans afflicted with HIV-Diseases, such as AIDS or ARC.

  人类免疫缺陷病毒（HIV）主要中和决定簇（PND）肽或与之具有相同免疫学结构的肽 具有以下结构的肽或与之免疫等效的肽 其中的环系统是通过稳定的酰胺键闭环形成的，可用作分析工具、酶联免疫吸附试验的试剂或制造共价结合免疫原的试剂。含有这些稳定环肽的共轭物可用于提高哺乳动物的抗肽、抗 HIV 或 HIV 中和免疫反应，含有这种共轭物的组合物可用作预防 HIV 疾病（包括获得性免疫缺陷综合征（AIDS）或 AIDS 相关综合征（ARC））的疫苗，或用作治疗人类 HIV 疾病（如 AIDS 或 ARC）的免疫原。
• Cyclic HIV principal neutralizing determinant (PNP) peptides
  申请人：MERCK & CO. INC.

  公开号：EP0551689A2

  公开（公告）日：1993-07-21

  Cyclic Human Immunodeficiency Virus (HIV) Principal Neutralizing Determinant (PND) peptides, or peptides immunologically equivalent therewith, wherein the ring system of the cyclic peptide is formed by ring closure through a stable amide bond, are useful as analytical tools, as reagents in ELISA assays, or as reagents for making covalent conjugate immunogens. Conjugates containing these stable, cyclic peptides are useful for raising mammalian anti-peptide, anti-HIV, or HIV-neutralizing immune responses, and a composition containing such a conjugate may be used as a vaccine to prevent HIV-Disease, including Acquired Immune Deficiency Syndrome, (AIDS), or AIDS related complex, (ARC), or as an immunogen for treating humans afflicted with HIV-Diseases, such as AIDS or ARC.

  环状人类免疫缺陷病毒（HIV）主要中和决定簇（PND）肽或与之免疫等效的肽，其中环肽的环系统是通过稳定的酰胺键闭环形成的，可用作分析工具、ELISA 检测试剂或制造共价结合免疫原的试剂。含有这些稳定环肽的共轭物可用于提高哺乳动物的抗肽、抗 HIV 或 HIV 中和免疫反应，含有这种共轭物的组合物可用作预防 HIV 疾病（包括获得性免疫缺陷综合征（AIDS）或 AIDS 相关综合征（ARC））的疫苗，或用作治疗人类 HIV 疾病（如 AIDS 或 ARC）的免疫原。
• Pneumococcal polysaccharide conjugate vaccine
  申请人：Merck & Co., Inc.

  公开号：EP0497525B1

  公开（公告）日：1998-08-19
• US5623057A
  申请人：——

  公开号：US5623057A

  公开（公告）日：1997-04-22