8-benzenesulfonyl-2-(4-tert-butyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one | 1255711-39-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 8-benzenesulfonyl-2-(4-tert-butyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
• 英文别名: 8-(Benzenesulfonyl)-2-(4-tert-butylphenyl)-2,8-diazaspiro[4.5]decan-1-one
• CAS: 1255711-39-7
• 化学式: C₂₄H₃₀N₂O₃S
• 分子量: 426.58
• InChiKey: LKUISIFXOBQQQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  66.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] AZACYCLIC SPIRODERIVATIVES AS HSL INHIBITORS<br/>[FR] SPIRODÉRIVÉS AZACYCLIQUES EN TANT QU'INHIBITEURS DE LA HSL
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010130665A1

  公开（公告）日：2010-11-18

  Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein n, m, A, R1 and R2 have the significance given in claim 1. The compounds are useful as HSL inhibitors for the treatment of diabetes dyslipidemia, atherosclerosis and obesity.

  式（I）的化合物及其药学上可接受的盐可以用作药物组合物的形式，其中n、m、A、R1和R2具有权利要求1中给出的含义。这些化合物可用作HSL抑制剂，用于治疗糖尿病脂质代谢紊乱、动脉粥样硬化和肥胖症。
• FORMULATIONS FOR THE DELIVERY OF ACTIVE AGENTS TO INSECTS, PLANTS, AND PLANT PATHOGENS
  申请人：Preceres Inc.

  公开号：US20170325457A1

  公开（公告）日：2017-11-16

  The present disclosure is directed to formulations comprising (1) at least one formulation transport agent, (2) at least one complexing agent, and (3) at least one active agent that modulates one or more traits of a target insect, plant, or plant pathogen. The present disclosure is also directed to methods of delivering such formulations to the target organism, as well as to formulation transport agents used to prepare such formulations.

  本公开涉及包含（1）至少一种制剂运输剂、（2）至少一种络合剂和（3）至少一种调节目标昆虫、植物或植物病原体的一个或多个特征的活性剂的配方。本公开还涉及将这种配方传递给目标生物体的方法，以及用于制备这种配方的制剂运输剂。
• Galenic formulation
  申请人：——

  公开号：US20030039619A1

  公开（公告）日：2003-02-27

  Cosmetic or dermatological formulations which comprise one or more active ingredients selected from phylloquinone, 2-hydroxy-5-methyllaurophenone oxime, vitamin A and its derivatives, vitamin E and its derivatives, vitamin H, allantoin, bisabolol, nicotinic acid derivatives and caffeine and in addition (a) one or more antioxidants and/or (b) one or more UV filters, are distinguished, in particular, by the fact that the active ingredients present in the formulation according to the invention are stabilised.

  本发明涉及一种化妆品或皮肤科配方，其包含从叶绿醌、2-羟基-5-甲基月桂酰苯肟、维生素A及其衍生物、维生素E及其衍生物、维生素H、尿囊素、甘菊醇、烟酸衍生物和咖啡因中选择的一种或多种活性成分，以及(a)一种或多种抗氧化剂和/或(b)一种或多种紫外线过滤剂，特别之处在于，根据本发明的配方中存在的活性成分是稳定的。
• NEW AZACYCLIC DERIVATIVES
  申请人：Ackermann Jean

  公开号：US20100292212A1

  公开（公告）日：2010-11-18

  The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, m, A, R 1 and R 2 have the significance given in the description. The compounds are useful as HSL inhibitors and may be used in the treatment or prophylaxis of diabetes, dyslipidemia, atherosclerosis or obesity.

  本发明涉及公式(I)的化合物及其药学上可接受的盐，其中n、m、A、R1和R2具有所述描述中给出的含义。这些化合物可用作HSL抑制剂，并可用于治疗或预防糖尿病、血脂异常、动脉粥样硬化或肥胖症。
• Compositions containing azole derivatives for topical application to skin
  申请人：UNILEVER PLC

  公开号：EP0747042A1

  公开（公告）日：1996-12-11

  Compositions for treating skin which contain azole in combination with a lipid ingredient. The compositions attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle an azole and a lipid ingredient.

  用于治疗皮肤的组合物含有唑与脂质成分。这种复合物可实现角质细胞分化并提供额外的益处。还公开了一种改善或预防皱纹、脱皮、老化、光损伤皮肤外观的方法，方法是在皮肤上涂抹一种在化妆品可接受载体中含有唑和脂质成分的组合物。