2-Nitro-5-sulfanylbenzamide | 923002-13-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Nitro-5-sulfanylbenzamide
• CAS: 923002-13-5
• 化学式: C7H6N2O3S
• 分子量: 198.2
• InChiKey: JDKOCHIBUFTGTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.9
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Substituted dithiobisnitrobenzenes and their applications
  申请人：Institut Pasteur De Lille

  公开号：US20030175848A1

  公开（公告）日：2003-09-18

  The invention concerns substituted dithio-bis-nitrobenzenes (dithio-bis-nitrobenzylamines, dithio-bis-nitrobenzamides or dithio-bis-nitrophenacyls) and their uses as alternative substrates for NAD(P)H-dependent disulphide-reductase enzymes, such as trypanothion reductase and thioredoxine reductase and as a means for screening inhibitors of said enzymes. The invention also concerns an enzymatic test using said substrates and assay kits containing them. Said dithio-bis-nitrobenzenes correspond to general formula (I).

  本发明涉及取代的二硫代双硝基苯（二硫代双硝基苄胺，二硫代双硝基苯甲酰胺或二硫代双硝基苯乙酰基）及其作为NAD（P）H依赖性二硫化物还原酶酶的替代底物的用途，例如trypanothion还原酶和thioredoxine还原酶，并作为筛选该酶抑制剂的手段。本发明还涉及使用所述底物的酶促测试和包含它们的检测试剂盒。所述二硫代双硝基苯对应于通式（I）。
• DITHIO-BIS-NITROBENZENES SUBSTITUES ET LEURS APPLICATIONS
  申请人：INSTITUT PASTEUR DE LILLE

  公开号：EP1082297B1

  公开（公告）日：2003-06-18
• [EN] SUBSTITUTED DITHIO-BIS-NITROBENZENES AND THEIR APPLICATIONS<br/>[FR] DITHIO-BIS-NITROBENZENES SUBSTITUES ET LEURS APPLICATIONS
  申请人：INSTITUT PASTEUR DE LILLE

  公开号：WO1999061416A1

  公开（公告）日：1999-12-02

  (EN) The invention concerns substituted dithio-bis-nitrobenzenes (dithio-bis-nitrobenzylamines, dithio-bis-nitrobenzamides or dithio-bis-nitrophenacyls) and their uses as alternative substrates for NAD(P)H-dependent disulphide-reductase enzymes, such as trypanothion reductase and thioredoxine reductase and as means for screening inhibitors of said enzymes. The invention also concerns an enzymatic test using said substrates and assay kits containing them. Said dithio-bis-nitrobenzenes correspond to general formula (I).(FR) Dithio-bis-nitrobenzènes substitués (dithio-bis-nitrobenzylamines, dithio-bis-nitrobenzamides ou dithio-bis-nitrophénacyles) ainsi que leurs applications comme substrats alternatifs des enzymes disulfure-réductases NAD (P)H-dépendantes, telles que la trypanothion réductase et la thiorédoxine réductase et comme moyen de criblage d'inhibiteurs de ces enzymes. Test enzymatique mettant en ooeuvre lesdits substrats ainsi que kit de dosage les contenant. Lesdits dithio-bis-nitrobenzènes substitués présentent la formule générale (I).